Endoscopic and electroporation therapy of paranasal sinus tumors

The purpose of this article is to introduce the concept of endoscopic and electroporation therapy for the treatment of sinonasal carcinomas. Electroporation therapy is a technique that combines intralesional injection of bleomycin combined with application of high-voltage square wave electrical impu...

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Bibliographic Details
Published in:American journal of rhinology 2000-05, Vol.14 (3), p.187-192
Main Authors: Panje, W R, Sadeghi, N
Format: Article
Language:English
Subjects:
Adenocarcinoma - therapy
Aged
Aged, 80 and over
Antibiotics, Antineoplastic - administration & dosage
Antibiotics, Antineoplastic - therapeutic use
Bleomycin - administration & dosage
Bleomycin - therapeutic use
Electroporation
Endoscopy
Humans
Injections, Intralesional
Male
Paranasal Sinus Neoplasms - therapy
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Summary:The purpose of this article is to introduce the concept of endoscopic and electroporation therapy for the treatment of sinonasal carcinomas. Electroporation therapy is a technique that combines intralesional injection of bleomycin combined with application of high-voltage square wave electrical impulse into the tumor. A transient increase in cell membrane permeability allows intracellular entry of bleomycin, with subsequent cytotoxicity. Two cases of sinonasal cancer were treated with this technique. One patient had complete response and is free of disease at 20 months. The other had partial response with control of the disease up to a year. Endoscopic electroporation therapy is potentially a minimally invasive method for the treatment of sinonasal malignancies in an experimental setting where other treatment options do not exist. Phase II/III national clinical trials have been initiated to study the efficacy of electroporation therapy.
ISSN:1050-6586
1945-8924
1539-6290
1945-8932
DOI:10.2500/105065800782102744