A Stability-Indicating HPLC Method to Determine Cyproterone Acetate in Tablet Formulations

A simple and accurate liquid chromatographic method was developed to estimate cyproterone acetate (CA) in pharmaceuticals. The drug was chromatographed on a reversed-phase C18 column. Eluents were monitored at a wavelength of 254 nm utilizing a mixture (60:40) of acetonitrile and water. Solution con...

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Bibliographic Details
Published in:Drug development and industrial pharmacy 2000-01, Vol.26 (8), p.867-872
Main Authors: Segall, Adriana, Vitale, Mirna, Perez, Vanina, Hormaechea, Florencia, Palacios, Marcelo, Pizzorno, María Teresa
Format: Article
Language:English
Subjects:
Analysis
Androgen Antagonists - chemistry
Biological and medical sciences
Chromatography, High Pressure Liquid - methods
Cyproterone acetate
Cyproterone Acetate - chemistry
General pharmacology
HPLC method
Medical sciences
Pharmacology. Drug treatments
Stability indicating
Tablets
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Summary:A simple and accurate liquid chromatographic method was developed to estimate cyproterone acetate (CA) in pharmaceuticals. The drug was chromatographed on a reversed-phase C18 column. Eluents were monitored at a wavelength of 254 nm utilizing a mixture (60:40) of acetonitrile and water. Solution concentrations were measured on a weight basis to avoid the use of an internal standard. The method was statistically validated for linearity, accuracy, precision, and selectivity. Due to its simplicity and accuracy, we believe that the method can be used for routine quality control analysis. No specific sample preparation is required except for the use of a column guard and a suitable prefilter attached to the syringe.
ISSN:0363-9045
1520-5762
DOI:10.1081/DDC-100101310