Lipids, Lipophilic Drugs, and Oral Drug Delivery—Some Emerging Concepts

Lipid‐based dose forms, which encompass a wide variety of compositional and functional characteristics, can be advantageously utilized for the formulation of lipophilic drugs. There has been a traditional reluctance to develop lipid‐based dose forms due to potential problems of chemical and physical...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2000-08, Vol.89 (8), p.967-978
Main Author: Charman, William N.
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
ATP Binding Cassette Transporter, Subfamily B, Member 1 - metabolism
Biological and medical sciences
Chemistry, Pharmaceutical
Drug Delivery Systems
formulation
General pharmacology
Humans
Intestinal Mucosa - metabolism
Intestines - cytology
lipid dose forms
Lipids - administration & dosage
Lipoproteins - blood
Lymphatic System - metabolism
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
poorly water soluble drugs
Solubility
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Description
Summary:Lipid‐based dose forms, which encompass a wide variety of compositional and functional characteristics, can be advantageously utilized for the formulation of lipophilic drugs. There has been a traditional reluctance to develop lipid‐based dose forms due to potential problems of chemical and physical instability, and a paucity of knowledge regarding formulation design algorithms and technology transfer issues. However, there is a current resurgence of interest in lipid‐based dose forms due to potential commercial and pharmaceutical benefits, and the industry trend towards the discovery/development of increasingly hydrophobic (and potent) new chemical entities. This mini‐review describes some emerging formulation and biopharmaceutic strategies that hold promise for better understanding how to design and evaluate lipid‐based dose forms. © 2000 Wiley‐Liss, Inc. and the American Pharmaceutical Association J Pharm Sci 89:967–978, 2000
ISSN:0022-3549
1520-6017
DOI:10.1002/1520-6017(200008)89:8<967::AID-JPS1>3.0.CO;2-R