Redox Regulation of Lymphocyte Signaling

Compelling evidence exists that reactive oxygen species can deliver intracellular signals in mammalian cells, and elicit a broad array of physiological responses according to the cell type, the oxidative burden and the cellular compartment where radicals are generated. When applied to immune cells,...

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Bibliographic Details
Published in:IUBMB life 2000-05, Vol.49 (5), p.381-389
Main Authors: Pani, Giovanni, Colavitti, Renata, Borrello, Silvia, Galeotti, Tommaso
Format: Article
Language:English
Subjects:
Activation
Animals
Cell Communication
Humans
Lymphocyte
Lymphocytes - cytology
Lymphocytes - metabolism
Lymphocytes - physiology
Models, Biological
Oxidation-Reduction
Oxygen
Phagocytes - cytology
Phosphatases
Phosphoric Monoester Hydrolases - metabolism
Reactive
Reactive Oxygen Species
Signal
Signal Transduction
Species
Transduction
Tyrosine
Tyrosine - metabolism
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Summary:Compelling evidence exists that reactive oxygen species can deliver intracellular signals in mammalian cells, and elicit a broad array of physiological responses according to the cell type, the oxidative burden and the cellular compartment where radicals are generated. When applied to immune cells, these concepts gain a particular relevance, in relation to the plasticity of immune functions and the biological complexity of lymphocyte response to antigens. Here we review some recent and somehow conflicting observations on the involvement of oxygen radicals and redox balance in lymphocyte activation, and propose models for how radical species could contribute to normal and pathological immunity.
ISSN:1521-6543
1521-6551
DOI:10.1080/152165400410227