Mitotically active cells that generate neurons and astrocytes are present in multiple regions of the adult mouse hippocampus

Previous studies of the adult hippocampus of rodents and primates have reported neuro‐ and gliogenesis restricted to the region of the dentate gyrus. In the present study, by employing a prolonged bromodeoxyuridine (BrdU) labeling protocol that attempts to account for cytokinetic changes as an anima...

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Bibliographic Details
Published in:Journal of comparative neurology (1911) 2000-08, Vol.424 (3), p.397-408
Main Authors: Rietze, Rodney, Poulin, Paule, Weiss, Samuel
Format: Article
Language:English
Subjects:
Age Factors
Ammon's horn
Animals
Astrocytes - cytology
Astrocytes - metabolism
Bromodeoxyuridine
CA1
Cell Count
Cell Differentiation - physiology
dentate gyrus
gliogenesis
Hippocampus - cytology
Hippocampus - growth & development
Hippocampus - metabolism
Male
Mice - anatomy & histology
Mice - growth & development
Mice - metabolism
Mice, Inbred Strains
Mitosis - physiology
neurogenesis
Neurons - cytology
Neurons - metabolism
Stem Cells - cytology
Stem Cells - metabolism
Thymidine
Time Factors
Tritium
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Summary:Previous studies of the adult hippocampus of rodents and primates have reported neuro‐ and gliogenesis restricted to the region of the dentate gyrus. In the present study, by employing a prolonged bromodeoxyuridine (BrdU) labeling protocol that attempts to account for cytokinetic changes as an animal ages, we have identified mitotically active cells in multiple regions of the hippocampus, especially in Ammon's horn, of the adult mouse. Immediately following the labeling period, the BrdU‐labeled cells did not express known markers for neurons and astrocytes. Subsequent analysis at 3–24 weeks after labeling demonstrated BrdU‐labeled neurons and glia in these regions of the hippocampus. Although neuro‐ and gliogenesis in the adult mammalian hippocampus have been reported previously, these results demonstrate that the phenomenon is not limited to the region of the dentate gyrus, but rather extends into Ammon's horn. Furthermore, it suggests that ongoing cell production, albeit discrete and limited in nature, may be widespread in the adult mammalian central nervous system. J. Comp. Neurol. 424:397–408, 2000. © 2000 Wiley‐Liss, Inc.
ISSN:0021-9967
1096-9861
DOI:10.1002/1096-9861(20000828)424:3<397::AID-CNE2>3.0.CO;2-A