Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease

In patients with Alzheimer's disease, but not in health controls, longitudinal magnetic resonance spectroscopy shows a striking decline in the neuronal marker, N-acetyl aspartate, despite little decline in underlying grey-matter volume.

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Bibliographic Details
Published in:The Lancet (British edition) 2000-05, Vol.355 (9216), p.1696-1697
Main Authors: Adalsteinsson, E, Sullivan, EV, Kleinhans, N, Spielman, DM, Pfefferbaum, A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - diagnosis
Alzheimer Disease - metabolism
Alzheimer's disease
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Biological and medical sciences
Brain - metabolism
Brain - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Progression
Female
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Medical sciences
Neurology
Neurons
Neurons - metabolism
Neurons - pathology
Prospective Studies
Scientific imaging
Sensitivity and Specificity
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Description
Summary:In patients with Alzheimer's disease, but not in health controls, longitudinal magnetic resonance spectroscopy shows a striking decline in the neuronal marker, N-acetyl aspartate, despite little decline in underlying grey-matter volume.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(00)02246-7