Mitral annular dynamics during rapid atrial pacing

Introduction: Ovine mitral annular area (MAA) reduction predominantly occurs before ventricular systole. We used the myocardial marker methods to investigate left atrial and MAA dynamics during rapid atrial pacing. Methods: Seven sheep underwent implantation of 21 myocardial markers around the mitra...

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Bibliographic Details
Published in:Surgery 2000-08, Vol.128 (2), p.361-367
Main Authors: Timek, Tomasz A., Lai, David T., Dagum, Paul, Green, G.Randall, Glasson, Julie R., Daughters, George T., Ingels, Neil B., Miller, D.Craig
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Atrial Fibrillation - physiopathology
Biological and medical sciences
Cardiac Pacing, Artificial
Diastole
Diseases of the cardiovascular system
Electrocardiography
Heart Rate - physiology
Hemodynamics
Medical sciences
Mitral Valve - physiology
Mitral Valve - physiopathology
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Sheep
Systole
Time Factors
Ventricular Function, Left
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Summary:Introduction: Ovine mitral annular area (MAA) reduction predominantly occurs before ventricular systole. We used the myocardial marker methods to investigate left atrial and MAA dynamics during rapid atrial pacing. Methods: Seven sheep underwent implantation of 21 myocardial markers around the mitral annulus, the left ventricle and left atrium. After 7 to 10 days, animals were studied with biplane videofluoroscopy to determine 3-dimensional marker coordinates unpaced and during rapid atrial pacing at 140 minutes–1. Left ventricle volume, left atrial volume (LAV), and MAA were calculated from marker coordinates. End diastole (ED) was defined at peak of the electrocardiogram R wave; times of minimum MAA and minimum LAV were expressed relative to ED (t = 0). Percent reduction in MAA and LAV were calculated from maximum and minimum values between diastole and early systole. Results: The time of minimum MAA occurred earlier relative to ED during rapid pacing compared with control (–48 ± 21 vs 19 ± 14 msec; P
ISSN:0039-6060
1532-7361
DOI:10.1067/msy.2000.108058