A Longitudinal Study of Apolipoprotein-E Genotype and Depressive Symptoms in Community-Dwelling Older Adults

The Apolipoprotein-E (APOE) ɛ4 allele is a risk factor for Alzheimer's disease (AD) and cognitive decline in older adults. Depression may also be a risk factor for dementia, and depression is important in the differential diagnosis of dementia. The authors performed a 5-year longitudinal study...

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Bibliographic Details
Published in:The American journal of geriatric psychiatry 2000, Vol.8 (3), p.196-200
Main Authors: Mauricio, Maritess, O'Hara, Ruth, Yesavage, Jerome A., Friedman, Leah, Kraemer, Helena C., Van De Water, Margaret, Murphy, Greer M.
Format: Article
Language:English
Subjects:
Age Factors
Aged
Aged, 80 and over
Alleles
Alzheimer Disease - genetics
Analysis of Variance
Apolipoprotein E4
Apolipoproteins E - genetics
Cognition
Depression - genetics
Depression - psychology
Female
Genotype
Humans
Longitudinal Studies
Male
Psychiatric Status Rating Scales
Residence Characteristics
Sampling Studies
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Summary:The Apolipoprotein-E (APOE) ɛ4 allele is a risk factor for Alzheimer's disease (AD) and cognitive decline in older adults. Depression may also be a risk factor for dementia, and depression is important in the differential diagnosis of dementia. The authors performed a 5-year longitudinal study of APOE genotype and change in Geriatric Depression Scale scores in 113 community-dwelling older adults. No association was observed between APOE genotype and change in depressive symptoms. These results do not support the hypothesis that the APOE ɛ4 allele is associated with depression. Important objections have been raised to APOE genotyping in the diagnosis of AD. However, the specificity of APOE genotyping in AD diagnosis would not appear to be compromised by an association with depression.
ISSN:1064-7481
1545-7214
DOI:10.1097/00019442-200008000-00003