Mitochondrial Oxidative Stress and Aging in the Filamentous Fungus Podospora anserina

: In the filamentous fungus Podospora anserina, mitochondrial oxidative stress is a major contributor to aging. Reactive oxygen species (ROS) generated as a result of electron leakage during respiration lead to damage of components of the electron transport chain. In aging wild‐type cultures, damage...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2000-06, Vol.908 (1), p.31-39
Main Authors: OSIEWACZ, HEINZ D., BORGHOUTS, CORINA
Format: Article
Language:English
Subjects:
Ascomycota - genetics
Ascomycota - physiology
Cell Compartmentation
DNA, Mitochondrial - physiology
Electron Transport
Electrons
Humans
Mitochondria - physiology
Oxidative Stress - physiology
Podospora anserina
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Summary:: In the filamentous fungus Podospora anserina, mitochondrial oxidative stress is a major contributor to aging. Reactive oxygen species (ROS) generated as a result of electron leakage during respiration lead to damage of components of the electron transport chain. In aging wild‐type cultures, damaged proteins cannot be replaced because the mitochondrial genes encoding some of the corresponding subunits gradually become deleted from the mitochondrial DNA (mtDNA). Consequently, these defects result in an increased generation of reactive oxygen species and respiration deficits leading to cell death. Analyses of wild‐type strains and of different long‐lived mutants of P. anserina provide strong evidence that molecular mechanisms controlling aging processes in this fungus are complex and act at different levels. A basic mechanism (e.g., damage by ROS) appears to be overlaid by prominent instabilities of the mtDNA.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2000.tb06633.x