Long-term prognosis of parathyroid function after successful percutaneous ethanol injection therapy (PEIT) guided by color Doppler flow mapping in chronic dialysis patients

• Published in: Biomedicine & pharmacotherapy 2000-06, Vol.54, p.60s-65s
• Main Authors: Kakuta, T., Kunimatsu, K., Tadaki, F., Fujisaki, T., Noguchi, M., Abe, Y., Sakai, H., Kurokawa, K., Saito, A.
• Format: Article
• Language: English
• Subjects: Adult; Aged; dialysis; Ethanol; ethanol injection; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic - complications; Male; Middle Aged; Parathyroid Glands - diagnostic imaging; Parathyroid Glands - physiology; Parathyroid Glands - surgery; parathyroid hormone; Parathyroid Hormone - blood; parathyroid hyperplasia; Prognosis; Renal Dialysis; renal failure; Ultrasonography, Doppler, Color; uremia
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/S0753-3322(00)80013-X

Secondary hyperparathyroidism (2 HPT) is a representative disease of dialysis osteopathy, with the lesion that makes fibrous osteitis and the parathyroid hyperplasia by the hyper secretion of parathyroid hormone (PTH). This research examines the usefulness of selective percutaneous ethanol injection therapy (PEIT) of parathyroid glands in order to treat and control for 2 HPT. PEIT was performed in 46 patients resistant to calcitriol pulse therapy and all glands larger than 5 mm in diameter were destroyed by ethanol guided by power Doppler flow mapping. Serum intact-PTH (iPTH) levels fell from 633.3 ± 359.9 to 226.3 ± 204.7 pg/ml, at three weeks and were maintained at 289.9 ± 222.4 pg/mL at one year after PEIT. Total alkaline phosphatase activity fell from 384.9 ± 160.1 to 234.0 ± 110.5 IU/L at one year after PEIT. In 19 patients, i-PTH levels fell into relative hypoparathyroidism (iPTH < 160 pg/mL) at three weeks after PEIT; however, they recovered at one year after PEIT (191.1 ± 29.6 pg/mL). In total, parathyroid function was maintained at optimal range (160 < iPTH < 360 pg/mL) in 80.4% of patients at one year after PEIT with appropriate medical therapy. As for the complications, recurrent nerve palsy was observed in only one patient, but was reversible. In conclusion, selective PEIT appears to be able to control appropriate parathyroid function and to be the method of choice to treat 2 HPT prior to parathyroidectomy.