A morphological and immunohistological study of the human and rabbit appendix for comparison with the avian bursa

Diversification of the primary antibody repertoire occurs in young rabbit appendix. As a prelude to molecular investigation of whether human appendix has a similar role, we compared the lymphoid morphology and distribution of common B- and T-cell subsets in frozen and/or paraffin-embedded normal app...

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Bibliographic Details
Published in:Developmental and comparative immunology 2000-12, Vol.24 (8), p.797-814
Main Authors: Dasso, Joseph F., Obiakor, Harold, Bach, Hanh, Anderson, Arthur O., Mage, Rose G.
Format: Article
Language:English
Subjects:
Adolescent
ADP-ribosyl Cyclase
ADP-ribosyl Cyclase 1
Adult
Age Factors
Aged
Aged, 80 and over
Animals
Antigens, CD
Antigens, Differentiation - analysis
Appendix - immunology
B-cell repertoire
B-Lymphocytes - immunology
Bursa of Fabricius - immunology
CD4 Antigens - analysis
CD8 Antigens - analysis
Chicken bursa
Chickens
Child
Child, Preschool
Germinal center
Germinal Center - immunology
Human appendix
Humans
Immunoglobulins - analysis
Immunohistochemistry
Infant
Infant, Newborn
Ki-67 Antigen - analysis
Lymphocyte Count
Lymphoid development
Lymphoid Tissue - growth & development
Lymphoid Tissue - immunology
Membrane Glycoproteins
Middle Aged
NAD+ Nucleosidase - analysis
Rabbit appendix
Rabbits
T-cell
T-Lymphocytes - immunology
Trihexosylceramides - analysis
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Summary:Diversification of the primary antibody repertoire occurs in young rabbit appendix. As a prelude to molecular investigation of whether human appendix has a similar role, we compared the lymphoid morphology and distribution of common B- and T-cell subsets in frozen and/or paraffin-embedded normal appendix specimens at various ages. IgA, IgM and IgG staining patterns were similar in frozen human and rabbit appendices. The elongated follicles of the young human and rabbit appendices regressed with age to resemble Peyer’s patches. Although similar in morphology to the bursa, human and rabbit appendix follicles differ in that they do not involute completely with age and contain significant numbers of germinal center (GC) T cells although the number is low early in life. If the human appendix functions as a primary lymphoid organ, it may occur during the first few months of age when the GC T-cell density is low.
ISSN:0145-305X
1879-0089
DOI:10.1016/S0145-305X(00)00033-1