SUSCEPTIBILITIES OF BACTERIA ISOLATED FROM PATIENTS WITH LOWER RESPIRATORY INFECTIOUS DISEASES TO ANTIBIOTICS (1998)

• Published in: Japanese journal of antibiotics 2000/05/25, Vol.53(5), pp.261-298
• Main Authors: IKEMOTO, HIDEO, MORI, TAKESHI, IGARI, JUN, OGURI, TOYOKO, TERAI, TSUGIO, INOUE, HIROSHI, NAKADATE, TOSHIHIDE, ITO, CHUICHI, YOSHIDA, TAKESHI, OHNO, SAO, OKADA, SHINJI, ARAKAWA, MASAAKI, GEJYO, FUMITAKE, IGARASHI, KENICHI, OKADA, MASAHIKO, OZAKI, KYOKO, AOKI, NOBUKI, KITAMURA, NOBUKO, SEKINE, OSAMU, SUZUKI, YASUTOSHI, KARASAWA, YASUO, NAKATA, KOUICHIRO, NAKATANI, TATSUO, INAGAWA, HIROKO, KUDO, KOUICHIRO, KOBAYASHI, NOBUYUKI, KONDO, TADASHI, KOBAYASHI, HIROYUKI, KAWAI, SHIN, TAKAYASU, SATOSHI, SHIMADA, KAORU, NAKANO, KUNIO, YOKOUCHI, HIROSHI, ITO, AKIRA, SUMITOMO, MIDORI, MATSUSHIMA, TOSHIHARU, NIKI, YOSHIHITO, ANDO, MASAYUKI, SUGA, MORITAKA, SATO, KEIZOU, TOSAKA, MASAKAZU, KOHNO, SHIGERU, TOMONO, KAZUNORI, MIYAZAKI, YOSHITSUGU, IZUMIKAWA, KOICHI, YAMAGUCHI, TOSHIYUKI, MOCHIDA, CHIKAKO, NASU, MASARU, NAGAI, HIROYUKI, YAMASAKI, TOHRU, NAKANO, TADAO
• Format: Article
• Language: Japanese
• Subjects: Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Bacteria - isolation & purification; Drug Resistance, Microbial; Humans; Respiratory Tract Infections - microbiology; Time Factors
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.53.261

The bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, since 1981. IKEMOTO et al. have been investigating susceptibilities of these isolates to various antibacterial agents and antibiotics, and analyzed some characteristics of the patients and isolates from them each year. Results obtained from these investigations are discussed. In these 18 institutions around the entire Japan, 532 strains of presumably etiological bacteria were isolated mainly from the sputa of 438 patients with lower respiratory tract infections during the period from October in 1998 to September in 1999. MICs of various antibacterial agents and antibiotics were determined against 85 strains of Staphylococcus aureus, 100 strains of Streptococcus pneumoniae, 96 strains of Haemophilus influenzae, 75 strains of Pseudomonas aeruginosa (non-mucoid strains), 6 strains of Pseudomonas aeruginosa (mucoid strains), 38 strains of Moraxella subgenus Branhamella catarrhalis, 26 strains of Klebsiella pneumoniae etc., and the susceptibilities of 517 strains were assessed except for those strains that died during transportation. S. aureus strains for which MICs of oxacillin (MPIPC) were higher than 4μg/ml (methicillin-resistant S. aureus: MRSA) accounted for 60.0%. Vancomycin (VCM) and arbekacin (ABK) showed the most potent activities against MRSA. But one of MRSA showed resistance to ABK with the MIC of 64μg/ml. The sensitive strains of MRSA to VCM have decreased. The frequency of penicillin (PC)-intermediate S. pneumoniae (PISP) +PC-resistant S. pneumoniae (PRSP) have increased in 46.0% for 1998 cpmparatively from 30.9% of 1997's. But PRSP decreased, and PISP increased into 39.0% of 1998 years from 19.8% of 1997's. Panipenem (PAPM), imipenem (IPM) and faropenem (FRPM) showed the most potent activities against S. pneumoniae with MIC80s of 0.125μg/ml or below. Against H. influenzae and M.(B.) catarrhalis, almost all the drugs showed good activities. The sensitive strains of them against ceftazidime (CAZ) decreased in 1997, but those have increased in 1998. Inversely, the susceptibility of them against cefotiam (CTM) had been higher in 1997, but those have been lower in 1998. Tobramycin (TOB) showed the most potent activity against P aeruginosa (both mucoid and non- mucoid strains). All drugs except ampicillin (ABPC) were active against K. pneumoniae. A quite few of K. pneumoniae showed low susceptibilities. Also, we inves