Long-term effects of growth hormone treatment on growth and puberty in patients with chronic renal insufficiency

Several prospective trials have shown that recombinant human growth hormone (GH) accelerates growth significantly during the first years of therapy, but the effects of long-term GH therapy with regard to long-term growth response and safety have not yet been established. Forty-five Dutch prepubertal...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2000-07, Vol.14 (7), p.701-706
Main Authors: Hokken-Koelega, A, Mulder, P, De Jong, R, Lilien, M, Donckerwolcke, R, Groothof, J
Format: Article
Language:English
Subjects:
Age
Blood
Child
Child Development - drug effects
Child, Preschool
Children & youth
Endocrinology
Female
Glomerular Filtration Rate - drug effects
Growth hormones
Hemodialysis
Human Growth Hormone - therapeutic use
Humans
Kidney Failure, Chronic - drug therapy
Kidney Failure, Chronic - physiopathology
Male
Pediatrics
Peritoneal dialysis
Puberty
Puberty - drug effects
Randomized Controlled Trials as Topic
Recombinant Proteins - therapeutic use
Time Factors
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Summary:Several prospective trials have shown that recombinant human growth hormone (GH) accelerates growth significantly during the first years of therapy, but the effects of long-term GH therapy with regard to long-term growth response and safety have not yet been established. Forty-five Dutch prepubertal children [28 boys, 17 girls, mean (SD) age 7.8 (3.4) years] with chronic renal insufficiency (CRI) and severe growth retardation started GH therapy between 1988 and 1991 within one of the randomized Dutch trials. Long-term GH therapy, in this study a maximum of 8 years, resulted in a sustained and significant improvement of height standard deviation score (SDS) compared with baseline values (P
ISSN:0931-041X
1432-198X
DOI:10.1007/s004670000340