Down-regulation of natural killer cells and of gamma/delta T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity?

A depletion of natural killer (NK) cells seems to play a role in the course of systemic lupus erythematosus (SLE) whereas the possible involvement in this disease of T cell receptor (TCR) gamma/delta positive T cells is still debated. The aim of this study was to evaluate the peripheral blood mononu...

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Bibliographic Details
Published in:Lupus 2000, Vol.9 (5), p.333-337
Main Authors: Riccieri, V, Spadaro, A, Parisi, G, Taccari, E, Moretti, T, Bernardini, G, Favaroni, M, Strom, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Autoimmunity
Child
Down-Regulation
Female
Humans
Killer Cells, Natural - immunology
Lupus Erythematosus, Systemic - immunology
Lymphocyte Count
Male
Middle Aged
Predictive Value of Tests
Prognosis
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocytes - immunology
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Summary:A depletion of natural killer (NK) cells seems to play a role in the course of systemic lupus erythematosus (SLE) whereas the possible involvement in this disease of T cell receptor (TCR) gamma/delta positive T cells is still debated. The aim of this study was to evaluate the peripheral blood mononuclear cells (PBMCs) that express NK surface markers CD16 and CD56 or gamma/delta TCR antigen in 58 SLE patients, investigating the possible role of these cell subsets involved in non-MHC-restricted cytotoxicity and their relationship with the main clinical and laboratory parameters. SLE patients had, with respect to controls, considerably decreased values of NK cells (P
ISSN:0961-2033
DOI:10.1191/096120300678828460