Down-regulation of natural killer cells and of gamma/delta T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity?

A depletion of natural killer (NK) cells seems to play a role in the course of systemic lupus erythematosus (SLE) whereas the possible involvement in this disease of T cell receptor (TCR) gamma/delta positive T cells is still debated. The aim of this study was to evaluate the peripheral blood mononu...

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Published in:Lupus 2000, Vol.9 (5), p.333-337
Main Authors: Riccieri, V, Spadaro, A, Parisi, G, Taccari, E, Moretti, T, Bernardini, G, Favaroni, M, Strom, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Autoimmunity
Child
Down-Regulation
Female
Humans
Killer Cells, Natural - immunology
Lupus Erythematosus, Systemic - immunology
Lymphocyte Count
Male
Middle Aged
Predictive Value of Tests
Prognosis
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocytes - immunology
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container_issue 5
container_start_page 333
container_title Lupus
container_volume 9
creator Riccieri, V
Spadaro, A
Parisi, G
Taccari, E
Moretti, T
Bernardini, G
Favaroni, M
Strom, R
description A depletion of natural killer (NK) cells seems to play a role in the course of systemic lupus erythematosus (SLE) whereas the possible involvement in this disease of T cell receptor (TCR) gamma/delta positive T cells is still debated. The aim of this study was to evaluate the peripheral blood mononuclear cells (PBMCs) that express NK surface markers CD16 and CD56 or gamma/delta TCR antigen in 58 SLE patients, investigating the possible role of these cell subsets involved in non-MHC-restricted cytotoxicity and their relationship with the main clinical and laboratory parameters. SLE patients had, with respect to controls, considerably decreased values of NK cells (P
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SLE patients had, with respect to controls, considerably decreased values of NK cells (P<0.0004 in percentage and P<0.00004 as absolute number), of non-MHC-restricted T cytotoxic lymphocytes (P<0.007 and P<0.0015, respectively) and of T cells expressing gamma/delta TCR (P<0.02 and P<0.004, respectively). The absolute numbers of these cell subsets positively correlated to each other (P<0.009). gamma/delta T cells inversely correlated with higher ESR values, both percentually (P<0. 006; r=-0.367) and in absolute number (P<0.009; r=-0.350). Moreover, the percentage values of this cell subset inversely correlated with higher levels of CRP (P<0.05; r=-0.256) while SLE patients with anti-SSB/La antibodies had lower values of T lymphocytes bearing gamma/delta TCR, both as percentage (P<0.008) and as absolute number (P<0.02). Our study indicates that non-MHC-restricted cytotoxicity, shared by NK, NK-like and gamma/delta T cells, may be down-regulated in SLE patients, owing to a significant reduction of these PBMC subsets. 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source SAGE
subjects Adolescent
Adult
Aged
Autoimmunity
Child
Down-Regulation
Female
Humans
Killer Cells, Natural - immunology
Lupus Erythematosus, Systemic - immunology
Lymphocyte Count
Male
Middle Aged
Predictive Value of Tests
Prognosis
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocytes - immunology
title Down-regulation of natural killer cells and of gamma/delta T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity?
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