Type IV collagen as an early marker for diabetic nephropathy in non-insulin-dependent diabetes mellitus

• Published in: Journal of diabetes and its complications 2000, Vol.14 (1), p.13-17
• Main Authors: Kotajima, Nobuo, Kimura, Takao, Kanda, Tsugiyasu, Obata, Kenichi, Kuwabara, Atsushi, Fukumura, Yukihito, Kobayashi, Isao
• Format: Article
• Language: English
• Subjects: Adult; Aged; Albuminuria - urine; Associated diseases and complications; Biological and medical sciences; Biomarkers - urine; Collagen - urine; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - therapy; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - urine; Diabetic nephropathy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Glycated Hemoglobin A - analysis; Humans; Hypertension - drug therapy; Hypertension - urine; Male; Medical sciences; Middle Aged; Non-insulin-dependent diabetes mellitus; Urinary albumin; Urinary transferrin; Urinary type IV collagen
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/S1056-8727(00)00064-7

We measured urinary albumin (U-Alb) and type IV collagen (uIV·C) in spot urine collected from 82 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 205 controls. Eighty-two NIDDM patients that had no increased excretion of either U-Alb or uIV·C were observed for 6 months. Prevalence of increased excretion of U-Alb and uIV·C at 6 months in these patients were 32.9%, and 62.2%, respectively. Increased excretion of uIV·C was detected in 27 patients without microalbuminuria. χ 2 analysis suggested that uIV·C was more sensitive than U-Alb, and that hypertension enhanced increased excretion of both U-Alb and uIV·C. uIV·C was significantly correlated ( P