DNA vaccines: a key for inducing long-term cellular immunity

Over the past few years, major advances in several areas of immunology have provided a foundation for the rational design of vaccines against diseases requiring cellular immunity. Among these advances are the cellular mechanisms by which DNA vaccines can sustain long-term humoral and cellular immuni...

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Bibliographic Details
Published in:Current Opinion in Immunology 2000-08, Vol.12 (4), p.442-447
Main Authors: Gurunathan, Sanjay, Wu, Chang-Yu, Freidag, Brenda L, Seder, Robert A
Format: Article
Language:English
Subjects:
AIDS/HIV
Animals
Antigen Presentation - immunology
Cellular immunity
Dendritic cells
DNA vaccines
Genetic Vectors
Humans
Immunity, Cellular
Intracellular infection
Leishmania major - immunology
Leishmaniasis, Cutaneous - immunology
Leishmaniasis, Cutaneous - prevention & control
Malaria - immunology
Malaria - prevention & control
Plasmids
Th1 Cells - immunology
Time Factors
Tuberculosis - immunology
Tuberculosis - prevention & control
Vaccines, DNA - immunology
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Summary:Over the past few years, major advances in several areas of immunology have provided a foundation for the rational design of vaccines against diseases requiring cellular immunity. Among these advances are the cellular mechanisms by which DNA vaccines can sustain long-term humoral and cellular immunity.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(00)00118-7