Identification of maze learning-associated genes in rat hippocampus by cDNA microarray

Long-term memory formation requires de novo RNA and protein synthesis. To assess gene-expression changes associated with learning and memory processes, we used cDNA microarray to analyze hippocampal gene expression in male Fischer-344 rats following training in a multiunit T-maze. Here, we report th...

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Bibliographic Details
Published in:Journal of molecular neuroscience 2001-12, Vol.17 (3), p.397-404
Main Authors: Luo, Y, Long, J M, Spangler, E L, Longo, D L, Ingram, D K, Weng, N P
Format: Article
Language:English
Subjects:
Animals
Gene Expression
Hippocampus - metabolism
Hippocampus - physiology
Kinases
Male
Maze Learning
Memory
Oligonucleotide Array Sequence Analysis
Proteins
Rats
Rats, Inbred F344
Reverse Transcriptase Polymerase Chain Reaction
Rodents
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Summary:Long-term memory formation requires de novo RNA and protein synthesis. To assess gene-expression changes associated with learning and memory processes, we used cDNA microarray to analyze hippocampal gene expression in male Fischer-344 rats following training in a multiunit T-maze. Here, we report the identification of 28 clones (18 known genes and 10 ESTs) for which expression increased after the maze learning. Some of the known genes appear to be involved in Ca2+ signaling, Ras activation, kinase cascades, and extracellular matrix (ECM) function, which may regulate neural transmission, synaptic plasticity, and neurogenesis. The gene-expression profile presented here provides the groundwork for future, more focused research to elucidate the contribution of these genes in learning and memory processes.
ISSN:0895-8696
0895-8696
1559-1166
DOI:10.1385/jmn:17:3:397