Progestin regulation of human endometrial function

A well-orchestrated sequence of events enables the human endometrium to become receptive to embryo implantation during a defined period in the menstrual cycle. Ovarian steroids, oestradiol and progesterone, regulate many of these functions in a highly co-ordinated manner. There are no experimental s...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2000-06, Vol.15 (suppl-1), p.74-80
Main Authors: Satyaswaroop, P.G., Tabibzadeh, S.
Format: Article
Language:English
Subjects:
Animals
Carcinoma
Crystallins - drug effects
Crystallins - genetics
Crystallins - metabolism
Embryo Implantation
Endometrial Neoplasms
endometrium
Endometrium - drug effects
Endometrium - physiology
Epithelial Cells
Female
Humans
Medroxyprogesterone Acetate - pharmacology
Mice
Mice, Nude
oestradiol
progesterone
Progesterone - pharmacology
Progesterone Congeners - pharmacology
Progestins - metabolism
Progestins - pharmacology
regulation
Transplantation, Heterologous
α crystallin
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Summary:A well-orchestrated sequence of events enables the human endometrium to become receptive to embryo implantation during a defined period in the menstrual cycle. Ovarian steroids, oestradiol and progesterone, regulate many of these functions in a highly co-ordinated manner. There are no experimental systems for critically examining the regulation of endometrial functions by steroid hormones, especially those responses restricted to the epithelium. Using an experimental xenograft model where the steroid responses of normal endometrium could be predictably recapitulated, the role of progesterone in the regulation of α crystallin B in the glandular epithelial cells of human endometrium was established.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/15.suppl_1.74