Diurnal rhythm of cholesterol biosynthesis in experimental chronic renal failure

Changes in lipid metabolism are an important risk factor for vascular complications during chronic renal failure (CRF). In experimental CRF hypercholesterolemia has been found to be the main lipid disorder. It is probably due to enhanced cholesterologenesis. Mechanisms of these changes remain poorly...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2001-12, Vol.228 (1-2), p.33-37
Main Authors: Chmielewski, M, Nieweglowski, T, Swierczynski, J, Rutkowski, B, Boguslawski, W
Format: Article
Language:English
Subjects:
Animals
Biosynthesis
Body Weight
Cholesterol
Cholesterol - biosynthesis
Circadian Rhythm - physiology
Creatinine - blood
Disease Models, Animal
Hypercholesterolemia - metabolism
Intestinal Mucosa - metabolism
Kidney diseases
Kidney Failure, Chronic - metabolism
Liver - metabolism
Male
Mevalonic Acid - metabolism
Mevalonic Acid - urine
Rats
Rats, Wistar
Risk factors
Rodents
Urea - blood
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Summary:Changes in lipid metabolism are an important risk factor for vascular complications during chronic renal failure (CRF). In experimental CRF hypercholesterolemia has been found to be the main lipid disorder. It is probably due to enhanced cholesterologenesis. Mechanisms of these changes remain poorly understood. It is well known that activity of cholesterologenesis undergoes a significant diurnal rhythm. However, there was no evidence that this rhythm is still present in the course of experimental CRF. Results of our studies indicate that in contrast to puromycin induced nephrotic syndrome, diurnal rhythm of cholesterologenesis in CRF rats is preserved both in liver and in the intestine tissue. Significant higher incorporation of tritiated water into cholesterol fraction was found in vivo both in liver as well as in intestine of CRF rats, as compared to control animals. Increased (with comparison to the controls) incorporation of 14C-acetate, and 3H-mevalonate into CRF rat liver sterols indicate that mechanism of enhanced cholesterologenesis is more complex than simply due to the elevated level of mevalonate (potential substrate for cholesterologenesis) which has been reported in plasma of CRF animals.
ISSN:0300-8177
1573-4919
DOI:10.1023/A:1013395921241