Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

Deletion of the 1,3-β- D-glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracel...

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Bibliographic Details
Published in:FEBS letters 2000-07, Vol.478 (1), p.84-88
Main Authors: Garcı́a-Rodriguez, L.J, Trilla, J.A, Castro, C, Valdivieso, M.H, Durán, A, Roncero, C
Format: Article
Language:English
Subjects:
Carrier Proteins - metabolism
Cell Division
Chitin
Chitin - biosynthesis
Chitin Synthase - biosynthesis
Chitin Synthase - metabolism
Chitin synthase III activity
Compensatory mechanism
Echinocandins
Enzyme Induction
Fungal Proteins - biosynthesis
Fungal Proteins - genetics
Fungal Proteins - metabolism
Fungal Proteins - physiology
Gene Deletion
Gene Expression Regulation, Fungal
Glucosyltransferases
Membrane Proteins - deficiency
Membrane Proteins - genetics
Membrane Proteins - physiology
Phenotype
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins
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Summary:Deletion of the 1,3-β- D-glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main components of the CSIII active complex.
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(00)01835-4