Factitious hearing loss and otorrhea in an adolescent boy

Asialo, or β 2, transferrin occurs in cerebrospinal fluid and a few other body fluids, e.g., perilymph and aqueous humor. It is used clinically as a marker protein to detect CSF otorrhea and rhinorrhea. Asialo-transferrin is separated from sialylated serum transferrin glycoforms by electrophoresis a...

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Bibliographic Details
Published in:Clinica chimica acta 2000-09, Vol.299 (1), p.205-209
Main Authors: Kelly, Robert H, Kelly, Charlotte M, Busis, Sidney N
Format: Article
Language:English
Subjects:
Asialoglycoproteins - analysis
Biological and medical sciences
Blotting, Western
Cerebrospinal Fluid Otorrhea - diagnosis
Child
Electrophoresis, Agar Gel
Ent. Stomatology
Hearing Loss, Bilateral - diagnosis
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Salivary transferrin
Transferrin - analogs & derivatives
Transferrin - analysis
Transferrin isoforms
β 2 Transferrin
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Summary:Asialo, or β 2, transferrin occurs in cerebrospinal fluid and a few other body fluids, e.g., perilymph and aqueous humor. It is used clinically as a marker protein to detect CSF otorrhea and rhinorrhea. Asialo-transferrin is separated from sialylated serum transferrin glycoforms by electrophoresis and detected by Western blotting. Potential pitfalls in interpreting Western blots occur when other transferrin isoforms approximate the migratory behavior of asialo-transferrin. In the present report an adolescent boy was seen by an otolaryngologist for otorrhea and acute hearing loss. The otorrhea fluid, subsequently identified as saliva, contained a transferrin isoform with electrophoretic mobility similar to that of asialo-transferrin.
ISSN:0009-8981
1873-3492
DOI:10.1016/S0009-8981(00)00279-5