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TrkA is necessary for the normal development of the murine thymus
Nerve growth factor (NGF) and its signal-transducing receptor TrkA are expressed in the thymus. However, their possible role during thymic organogenesis is unknown. Here we analyze the thymus of trkA-kinase deficient 2-week-old mice. trkA-kinase +/+ and +/− mice had a normal thymus, whereas the thym...
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| Published in: | Journal of neuroimmunology 2000-08, Vol.108 (1), p.11-21 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c392t-2453a2468c48023467db869387304f2375df754d30846231a4495aae7b4f361f3 |
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| cites | cdi_FETCH-LOGICAL-c392t-2453a2468c48023467db869387304f2375df754d30846231a4495aae7b4f361f3 |
| container_end_page | 21 |
| container_issue | 1 |
| container_start_page | 11 |
| container_title | Journal of neuroimmunology |
| container_volume | 108 |
| creator | Garcı́a-Suárez, Olivia Germanà, Antonino Hannestad, Jonas Ciriaco, Emilia Laurà, Rosalba Naves, Javier Esteban, Isabel Silos-Santiago, Inmaculada Vega, José A. |
| description | Nerve growth factor (NGF) and its signal-transducing receptor TrkA are expressed in the thymus. However, their possible role during thymic organogenesis is unknown. Here we analyze the thymus of
trkA-kinase deficient 2-week-old mice.
trkA-kinase +/+ and +/− mice had a normal thymus, whereas the thymus of
trkA-kinase −/− mice showed lack of delimitation between the cortex and medulla, lower thymocyte density, and the presence of epithelial cell islands and numerous cysts lined with endodermal epithelium. The present results indicate that TrkA is necessary for the normal development of the thymus, and that its absence causes an arrest in the differentiation of endodermal epithelial cells. Whether this lack of differentiation has functional implication has yet to be determined. |
| doi_str_mv | 10.1016/S0165-5728(00)00251-4 |
| format | article |
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trkA-kinase deficient 2-week-old mice.
trkA-kinase +/+ and +/− mice had a normal thymus, whereas the thymus of
trkA-kinase −/− mice showed lack of delimitation between the cortex and medulla, lower thymocyte density, and the presence of epithelial cell islands and numerous cysts lined with endodermal epithelium. The present results indicate that TrkA is necessary for the normal development of the thymus, and that its absence causes an arrest in the differentiation of endodermal epithelial cells. Whether this lack of differentiation has functional implication has yet to be determined.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(00)00251-4</identifier><identifier>PMID: 10900332</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Body Weight ; Cell Differentiation ; Cysts - metabolism ; Cysts - pathology ; Cysts - ultrastructure ; Development ; Embryonic and Fetal Development ; Epithelial Cells - metabolism ; Epithelial Cells - pathology ; Epithelial Cells - ultrastructure ; Gene Deletion ; Heterozygote ; Homozygote ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Electron ; nerve growth factor ; Neurotrophins ; Organ Size ; Receptor, trkA - genetics ; Receptor, trkA - metabolism ; Thymus ; Thymus Gland - abnormalities ; Thymus Gland - embryology ; Thymus Gland - pathology ; Thymus Gland - ultrastructure ; TrkA ; TrkA protein</subject><ispartof>Journal of neuroimmunology, 2000-08, Vol.108 (1), p.11-21</ispartof><rights>2000 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-2453a2468c48023467db869387304f2375df754d30846231a4495aae7b4f361f3</citedby><cites>FETCH-LOGICAL-c392t-2453a2468c48023467db869387304f2375df754d30846231a4495aae7b4f361f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10900332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcı́a-Suárez, Olivia</creatorcontrib><creatorcontrib>Germanà, Antonino</creatorcontrib><creatorcontrib>Hannestad, Jonas</creatorcontrib><creatorcontrib>Ciriaco, Emilia</creatorcontrib><creatorcontrib>Laurà, Rosalba</creatorcontrib><creatorcontrib>Naves, Javier</creatorcontrib><creatorcontrib>Esteban, Isabel</creatorcontrib><creatorcontrib>Silos-Santiago, Inmaculada</creatorcontrib><creatorcontrib>Vega, José A.</creatorcontrib><title>TrkA is necessary for the normal development of the murine thymus</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Nerve growth factor (NGF) and its signal-transducing receptor TrkA are expressed in the thymus. However, their possible role during thymic organogenesis is unknown. Here we analyze the thymus of
trkA-kinase deficient 2-week-old mice.
trkA-kinase +/+ and +/− mice had a normal thymus, whereas the thymus of
trkA-kinase −/− mice showed lack of delimitation between the cortex and medulla, lower thymocyte density, and the presence of epithelial cell islands and numerous cysts lined with endodermal epithelium. The present results indicate that TrkA is necessary for the normal development of the thymus, and that its absence causes an arrest in the differentiation of endodermal epithelial cells. Whether this lack of differentiation has functional implication has yet to be determined.</description><subject>Animals</subject><subject>Body Weight</subject><subject>Cell Differentiation</subject><subject>Cysts - metabolism</subject><subject>Cysts - pathology</subject><subject>Cysts - ultrastructure</subject><subject>Development</subject><subject>Embryonic and Fetal Development</subject><subject>Epithelial Cells - metabolism</subject><subject>Epithelial Cells - pathology</subject><subject>Epithelial Cells - ultrastructure</subject><subject>Gene Deletion</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Immunohistochemistry</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Microscopy, Electron</subject><subject>nerve growth factor</subject><subject>Neurotrophins</subject><subject>Organ Size</subject><subject>Receptor, trkA - genetics</subject><subject>Receptor, trkA - metabolism</subject><subject>Thymus</subject><subject>Thymus Gland - abnormalities</subject><subject>Thymus Gland - embryology</subject><subject>Thymus Gland - pathology</subject><subject>Thymus Gland - ultrastructure</subject><subject>TrkA</subject><subject>TrkA protein</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkE1Lw0AQhhdRbK3-BCUn0UN09ntzklL8goIH63lJkwlGk2zdTQr996ZNEW-9zAzMM_PCQ8glhTsKVN2_90XGUjNzA3ALwCSNxREZU6NZbASjx2T8h4zIWQhfAFRykZySEYUEgHM2JtOF_55GZYgazDCE1G-iwvmo_cSocb5OqyjHNVZuVWPTRq7YberOlw3246buwjk5KdIq4MW-T8jH0-Ni9hLP355fZ9N5nPGEtTETkqdMKJMJA4wLpfOlUQk3moMoGNcyL7QUOQcjFOM0FSKRaYp6KQquaMEn5Hr4u_Lup8PQ2roMGVZV2qDrgtWUKWmUOQhSrZROqOpBOYCZdyF4LOzKl3WvwFKwW8l2J9luDVoAu5NsRX93tQ_oljXm_64Gqz3wMADY-1iX6G3ISmwyzEuPWWtzVx6I-AVmi4k5</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>Garcı́a-Suárez, Olivia</creator><creator>Germanà, Antonino</creator><creator>Hannestad, Jonas</creator><creator>Ciriaco, Emilia</creator><creator>Laurà, Rosalba</creator><creator>Naves, Javier</creator><creator>Esteban, Isabel</creator><creator>Silos-Santiago, Inmaculada</creator><creator>Vega, José A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>TrkA is necessary for the normal development of the murine thymus</title><author>Garcı́a-Suárez, Olivia ; 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However, their possible role during thymic organogenesis is unknown. Here we analyze the thymus of
trkA-kinase deficient 2-week-old mice.
trkA-kinase +/+ and +/− mice had a normal thymus, whereas the thymus of
trkA-kinase −/− mice showed lack of delimitation between the cortex and medulla, lower thymocyte density, and the presence of epithelial cell islands and numerous cysts lined with endodermal epithelium. The present results indicate that TrkA is necessary for the normal development of the thymus, and that its absence causes an arrest in the differentiation of endodermal epithelial cells. Whether this lack of differentiation has functional implication has yet to be determined.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>10900332</pmid><doi>10.1016/S0165-5728(00)00251-4</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 2000-08, Vol.108 (1), p.11-21 |
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| language | eng |
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| source | Elsevier |
| subjects | Animals Body Weight Cell Differentiation Cysts - metabolism Cysts - pathology Cysts - ultrastructure Development Embryonic and Fetal Development Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - ultrastructure Gene Deletion Heterozygote Homozygote Immunohistochemistry Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron nerve growth factor Neurotrophins Organ Size Receptor, trkA - genetics Receptor, trkA - metabolism Thymus Thymus Gland - abnormalities Thymus Gland - embryology Thymus Gland - pathology Thymus Gland - ultrastructure TrkA TrkA protein |
| title | TrkA is necessary for the normal development of the murine thymus |
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