Effect of Luffa echinata on Lipid Peroxidation and Free Radical Scavenging Activity

The dried alcoholic (50%) extract of the plant Luffa echinata was investigated for inhibition of lipid peroxidation, for hydroxyl radical scavenging activity and interaction with 1,1‐diphenyl‐2‐picrylhydrazyl stable free radical (DPPH). It was found that the test extract exhibited a considerable inh...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2000-07, Vol.52 (7), p.891-894
Main Authors: KUMAR, V. PRASHANTH, SHASHIDHARA, S., KUMAR, M. M., SRIDHARA, B. Y.
Format: Article
Language:English
Subjects:
Animals
Bepridil - analogs & derivatives
Bepridil - metabolism
Biological and medical sciences
Biphenyl Compounds
Cucurbitaceae - chemistry
Ethanol - chemistry
Free Radical Scavengers - metabolism
General pharmacology
Hydroxyl Radical - metabolism
In Vitro Techniques
Lipid Peroxidation - drug effects
Liver - drug effects
Liver - metabolism
Male
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Picrates
Plant Extracts - pharmacology
Rats
Rats, Wistar
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Summary:The dried alcoholic (50%) extract of the plant Luffa echinata was investigated for inhibition of lipid peroxidation, for hydroxyl radical scavenging activity and interaction with 1,1‐diphenyl‐2‐picrylhydrazyl stable free radical (DPPH). It was found that the test extract exhibited a considerable inhibition of lipid peroxidation and possessed hydroxyl radical scavenging activity. Evaluation of antiradical scavenging activity showed significant interaction with DPPH. These properties could be considered as a useful and exploitable combination for justifying the reported activity.
ISSN:0022-3573
2042-7158
DOI:10.1211/0022357001774589