Nitric oxide as a factor of genetically determined resistance to stress damages and adaptive protection

August rats are more resistant to stress-induced gastric damages than Wistar rats. These interstrain differences were abolished after blockade of nitric oxide (NO) synthesis with NO-synthase inhibitor L-NNA, which indicates that NO contributes to genetically determined resistance to stress-induced i...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2001-11, Vol.132 (5), p.1048-1050
Main Authors: Pshennikova, M G, Bondarenko, N A, Shimkovich, M V
Format: Article
Language:English
Subjects:
Animals
Digestive System - metabolism
Enzyme Inhibitors - pharmacology
Hypoxia
Male
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - metabolism
Nitroarginine - pharmacology
Oxidative Stress
Rats
Rats, Wistar
Species Specificity
Stress, Physiological
Time Factors
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Summary:August rats are more resistant to stress-induced gastric damages than Wistar rats. These interstrain differences were abolished after blockade of nitric oxide (NO) synthesis with NO-synthase inhibitor L-NNA, which indicates that NO contributes to genetically determined resistance to stress-induced injuries. Repeated treatment with L-NNA caused gastric ulceration in Wistar, but not in August rats. This is probably related to higher basal production and more intensive accumulation of NO in August rats compared to Wistar rats. Administration of L-NNA during adaptation to hypoxia suppressed its protective effects on the stomach in stress, which indicates that NO acts as the factor of adaptive protection.
ISSN:0007-4888
1573-8221