Cardiovascular risk and therapeutic benefit of coronary interventions for patients with unstable angina according to the troponin T status

Aims Elevation of troponin T in patients with unstable angina is predictive of adverse outcomes. Since no advanced therapeutic concept for such high-risk patients has been established, we investigated cardiac risk prior to, during, and after coronary revascularization in patients with unstable angin...

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Bibliographic Details
Published in:European heart journal 2000-07, Vol.21 (14), p.1159-1166
Main Authors: Heeschen, C., Goldmann, B.U., Terres, W., Hamm, C.W.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angina, Unstable - blood
Angina, Unstable - diagnostic imaging
Angina, Unstable - surgery
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Coronary Angiography
Coronary heart disease
coronary intervention
Decision Making
Electrocardiography
Female
Heart
Humans
Male
Medical sciences
Middle Aged
Myocardial Revascularization - methods
prognosis
Risk Assessment
Severity of Illness Index
troponin T
Troponin T - blood
Unstable angina
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Summary:Aims Elevation of troponin T in patients with unstable angina is predictive of adverse outcomes. Since no advanced therapeutic concept for such high-risk patients has been established, we investigated cardiac risk prior to, during, and after coronary revascularization in patients with unstable angina stratified according to the troponin T status. Methods and Results Out of 351 patients with unstable angina, troponin was elevated for 36% of the patients as determined by qualitative bedside tests. The patients were followed during hospitalization and 30 days after discharge for incidence of death and myocardial infarction. In troponin-positive patients, clinical symptoms were more refractory to medical treatment than in troponin-negative patients (78% vs 44%;P=0·002). Although these patients were catheterized earlier (1·6 vs 3·4 days;P=0·005) and more frequently (95% vs 69%;P
ISSN:0195-668X
1522-9645
DOI:10.1053/euhj.1999.1986