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Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke

There is still conflicting evidence regarding a link between alcohol drinking and the risk of stroke. In most prospective studies, the assessment of the alcohol drinking has been based on self-reporting, which may be unreliable. The aim of the present study was to examine the relationship between st...

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Published in:Stroke (1970) 2000-08, Vol.31 (8), p.1851-1855
Main Authors: JOUSILAHTI, P, RASTENYTE, D, TUOMILEHTO, J
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cited_by cdi_FETCH-LOGICAL-c468t-7032658254d354d4b4e8f058eb4525cb8a89ab1e0387abce6763169f8715a9543
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container_end_page 1855
container_issue 8
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container_title Stroke (1970)
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creator JOUSILAHTI, P
RASTENYTE, D
TUOMILEHTO, J
description There is still conflicting evidence regarding a link between alcohol drinking and the risk of stroke. In most prospective studies, the assessment of the alcohol drinking has been based on self-reporting, which may be unreliable. The aim of the present study was to examine the relationship between stroke and both the self-reported alcohol drinking and the serum gamma-glutamyl transferase (GGT) concentration, which was regarded as a biological marker of alcohol drinking. A prospective cohort study of 14 874 Finnish men and women aged 25 to 64 years who participated in a cardiovascular risk-factor survey in 1982 or 1987. The following risk factors, determined at baseline, were included in data analyses: self-reported alcohol drinking, GGT, smoking, blood pressure, serum cholesterol, and body mass index. The cohorts were followed until the end of 1994. Stroke events were identified through the national death registry and hospital discharge registry by computerized record linkage. Serum GGT concentration was associated with the risk of total and ischemic stroke in both genders. There was also a significant association among men between GGT and the risk of intracerebral hemorrhage and among women between GGT and the risk of subarachnoid hemorrhage. The relationships remained statistically significant also after adjustment for other risk factors. Self-reported alcohol drinking did not associate with any type of stroke. These results support the hypothesis that excessive alcohol drinking is related to an increased risk of stroke. Biological markers of alcohol drinking, such as serum GGT level, are useful for the assessment of risks related to alcohol drinking.
doi_str_mv 10.1161/01.str.31.8.1851
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There was also a significant association among men between GGT and the risk of intracerebral hemorrhage and among women between GGT and the risk of subarachnoid hemorrhage. The relationships remained statistically significant also after adjustment for other risk factors. Self-reported alcohol drinking did not associate with any type of stroke. These results support the hypothesis that excessive alcohol drinking is related to an increased risk of stroke. 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subjects Adult
Alcohol Drinking - adverse effects
Alcohol Drinking - blood
Biological and medical sciences
Biomarkers - blood
Female
Finland - epidemiology
gamma-Glutamyltransferase - blood
Humans
Incidence
Male
Medical sciences
Middle Aged
Neurology
Prospective Studies
Registries - statistics & numerical data
Risk Factors
Self Disclosure
Stroke - enzymology
Stroke - epidemiology
Stroke - etiology
Surveys and Questionnaires
Survival Rate
Vascular diseases and vascular malformations of the nervous system
title Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke
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