Long-term results of topical nitroglycerin in the treatment of chronic anal fissures are disappointing

• Published in: Techniques in coloproctology 2001-12, Vol.5 (3), p.143-147
• Main Authors: Graziano, A, Svidler López, L, Lencinas, S, Masciangioli, G, Gualdrini, U, Bisisio, O
• Format: Article
• Language: English
• Subjects: Acute Disease; Administration, Topical; Adult; Aged; Chronic Disease; Female; Fissure in Ano - drug therapy; Follow-Up Studies; Humans; Male; Middle Aged; Nitroglycerin - administration & dosage; Prospective Studies; Recurrence; Treatment Outcome; Wound Healing
• ISSN: 1123-6337; 1128-045X
• DOI: 10.1007/s101510100016

Several treatments for anal fissure offer different responses and risks for complications. Reversible chemical sphincterotomy with topical nitroglycerin is an alternative to surgical sphincterotomy. The aim of this observational prospective study was to compare the effectiveness of topical nitroglycerin with the conventional medical treatment. Forty-three patients with anal fissure were treated: 22 (16 chronic and 6 acute) received 0.25% nitroglycerin topically, and 21 (16 chronic and 5 acute) received conventional treatment. Nitroglycerin or placebo was administered in two daily applications for two weeks. Median follow-up was 39 weeks. Healing rate with NTG was 75% for chronic and 83% for acute fissures, but recurrence rate for chronic fissures at 9 months was 67%. Healing rate with placebo for chronic fissures was only anecdotical (1 out of 16 patients). Headache as side effects occurred in 17 cases (77%). In conclusion, both treatments were effective for acute fissures, whereas for chronic ones NTG had a high healing rate but also a high recurrence rate.