Heritability of elevated factor VIII antigen levels in factor V Leiden families with thrombophilia

Factor VIII activity (factor VIII:C) and factor VIII antigen (factor VIII:Ag) levels above150 IU/dl are associated with a five‐ to sixfold increased risk of venous thrombosis compared with levels

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Bibliographic Details
Published in:British journal of haematology 2000-06, Vol.109 (3), p.519-522
Main Authors: Kamphuisen, P. W., Lensen, R., Houwing‐Duistermaat, J. J., Eikenboom, J. C. J., Harvey, M., Bertina, R. M., Rosendaal, F. R.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Autoantigens - blood
Biological and medical sciences
Blood and lymphatic vessels
Blood Group Antigens
Cardiology. Vascular system
Case-Control Studies
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Factor V
factor V Leiden
factor VIII
Factor VIII - immunology
familial clustering
Female
Genetic Predisposition to Disease
Hematologic and hematopoietic diseases
Hematology
Humans
Male
Medical sciences
Middle Aged
Platelet diseases and coagulopathies
Risk Factors
thrombophilia
Thrombophilia - blood
Thrombophilia - genetics
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Description
Summary:Factor VIII activity (factor VIII:C) and factor VIII antigen (factor VIII:Ag) levels above150 IU/dl are associated with a five‐ to sixfold increased risk of venous thrombosis compared with levels
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2000.02091.x