Synthesis and biological activities of an α-methyl and a β-methyl carbapenem and the corresponding unsubstituted compound

The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of β-lactam hydrolysis and their biological activities, particularly their β-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-06, Vol.10 (12), p.1389-1391
Main Authors: Pfaendler, Hans Rudolf, Weishaupt, Ralf, Meffert, Helmut
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Carbapenems - chemical synthesis
Carbapenems - chemistry
Carbapenems - pharmacology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
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Description
Summary:The carbapenem potassium salts 4, 7 and 8 were prepared. Their rates of β-lactam hydrolysis and their biological activities, particularly their β-lactamase inhibiting properties, were examined and explained on the basis of their different substitution and pyramidality.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00248-1