Restoration on tissue antioxidants by fenugreek seeds (Trigonella Foenum Graecum) in alloxan-diabetic rats

The influence of fenugreek seed powder supplementation in the diet on lipid peroxidation and antioxidant status was studied in normal and alloxan-diabetic rats. The protective effect of the aqueous extract of the seeds on the activity of calcium-dependent adenosinetriphosphatase (Ca2+ ATPase) in liv...

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Bibliographic Details
Published in:Indian journal of physiology and pharmacology 2001-10, Vol.45 (4), p.408-420
Main Authors: Anuradha, C V, Ravikumar, P
Format: Article
Language:English
Subjects:
Alloxan
Animals
Antioxidants - metabolism
Body Weight - drug effects
Calcium-Transporting ATPases - metabolism
Catalase - metabolism
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Eating - drug effects
Hypoglycemic Agents - therapeutic use
Lipid Peroxidation
Male
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Superoxide Dismutase - metabolism
Trigonella
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Summary:The influence of fenugreek seed powder supplementation in the diet on lipid peroxidation and antioxidant status was studied in normal and alloxan-diabetic rats. The protective effect of the aqueous extract of the seeds on the activity of calcium-dependent adenosinetriphosphatase (Ca2+ ATPase) in liver homogenate in the presence of Fe2+/ascorbate in vitro was also investigated. Normal and diabetic rats were provided with a diet supplemented with fenugreek seed powder for 30 days at a dosage of 2 g/kg body weight. The diabetic rats exhibited enhanced lipid peroxidation and increased susceptibility to oxidative stress associated with depletion of antioxidants in liver, kidney and pancreas. However, treatment with fenugreek seed powder normalised the alterations. In normal rats supplementation resulted in increased antioxidant status with reduction in peroxidation. Ca2+ ATPase activity in liver was protected by the aqueous extract to nearly 80% of the initial activity. The findings suggest that the soluble portion of the seeds could be responsible for the antioxidant property.
ISSN:0019-5499