Hopanoids are formed during transition from substrate to aerial hyphae in Streptomyces coelicolor A3(2)

Abstract Streptomyces coelicolor A3(2) contains a cluster of putative isoprenoid and hopanoid biosynthetic genes. The strain does not produce the pentacyclic hopanoids in liquid culture but produces them on solid medium when sporulating. Mutants defective in the formation of aerial mycelium and spor...

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Bibliographic Details
Published in:FEMS microbiology letters 2000-08, Vol.189 (1), p.93-95
Main Authors: Poralla, Karl, Muth, Günther, Härtner, Thomas
Format: Article
Language:English
Subjects:
Bacteriology
Biological and medical sciences
Culture Media
Differentiation
Fundamental and applied biological sciences. Psychology
Growth, nutrition, cell differenciation
Hopanoid
Hyphae
Isoprenoid
Lipid Metabolism
Liquid culture
Membrane permeability
Membranes
Microbiology
Spores
Streptomyces - genetics
Streptomyces - growth & development
Streptomyces - metabolism
Streptomyces coelicolor
Substrates
Triterpenes - metabolism
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Summary:Abstract Streptomyces coelicolor A3(2) contains a cluster of putative isoprenoid and hopanoid biosynthetic genes. The strain does not produce the pentacyclic hopanoids in liquid culture but produces them on solid medium when sporulating. Mutants defective in the formation of aerial mycelium and spores (bld), with the exception of bldB, do not synthesize hopanoids, whereas mutants, which form aerial mycelium but no spores (whi), do. The membrane condensing hopanoids possibly may alleviate stress in aerial mycelium by diminishing water permeability across the membrane.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.2000.tb09212.x