Persistence of Human Papillomavirus Type 16 Infection Is Associated with Lack of Cytotoxic T Lymphocyte Response to the E6 Antigens

Our cross-sectional study suggested that cytotoxic T lymphocyte (CTL) responses have a protective effect in squamous intraepithelial lesion (SIL) development. More CTL responses in women with human papillomavirus type 16 (HPV 16) infection without SILs than with SILs were detected. In the current lo...

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Bibliographic Details
Published in:The Journal of infectious diseases 2000-08, Vol.182 (2), p.595-598
Main Authors: Nakagawa, Mayumi, Stites, Daniel P., Patel, Sandeep, Farhat, Sepideh, Scott, Mark, Hills, Nancy K., Palefsky, Joel M., Moscicki, Anna-Barbara
Format: Article
Language:English
Subjects:
Adolescent
Adult
AE6 protein
Antigens
Biological and medical sciences
Cancer
Cell lines
Cervical cancer
Cohort Studies
Concise Comunications
E6 protein
Epitopes
Female
Human papillomavirus 16
Human viral diseases
Humans
Infections
Infectious diseases
Lesions
Longitudinal studies
Medical sciences
Oncogene Proteins, Viral - immunology
Papillomaviridae - immunology
Papillomaviridae - isolation & purification
Papillomavirus Infections - immunology
Polymerase chain reaction
Repressor Proteins
T lymphocytes
T-Lymphocytes, Cytotoxic - immunology
Tumor Virus Infections - immunology
Viral diseases
Viral diseases of the genital and urinary system
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Summary:Our cross-sectional study suggested that cytotoxic T lymphocyte (CTL) responses have a protective effect in squamous intraepithelial lesion (SIL) development. More CTL responses in women with human papillomavirus type 16 (HPV 16) infection without SILs than with SILs were detected. In the current longitudinal study, the role of CTL in clearing HPV 16 infection in women without SILs was investigated. Women with HPV 16 infection (n = 51) were enrolled, along with HPV 16—negative control women (n = 3). Twenty-two (55%) of 40 women who cleared HPV 16 infection had an E6 CTL response at least once, compared with none of 9 women who had HPV 16 persistence (P = .003). Such a difference was not demonstrated for E7; 25 (63%) of 40 women who cleared HPV 16 infection responded, versus 5 (56%) of 9 women with persistence (P = .720). It appears that lack of response to E6 is important in the persistence of HPV 16 infection.
ISSN:0022-1899
1537-6613
DOI:10.1086/315706