Stepwise Evolution of the Structure and Electronic Properties of DNA

The optical properties of a family of duplex DNA conjugates possessing from 1 to 11 A:T base pairs and covalently attached stilbene chromophores at both ends have been investigated. As few as from two to four base bairs are needed to establish base-pair absorption and circular dichroism spectra simi...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2003-10, Vol.125 (42), p.12729-12731
Main Authors: Lewis, Frederick D, Liu, Xiaoyang, Wu, Yansheng, Zuo, Xiaobing
Format: Article
Language:English
Subjects:
Biological and medical sciences
Circular Dichroism
DNA - chemistry
Electronic structure
Fundamental and applied biological sciences. Psychology
Models, Molecular
Molecular biophysics
Nucleic Acid Conformation
Oligonucleotides - chemistry
Poly A - chemistry
Poly T - chemistry
Spectrophotometry, Ultraviolet
Stilbenes - chemistry
Structure in molecular biology
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Summary:The optical properties of a family of duplex DNA conjugates possessing from 1 to 11 A:T base pairs and covalently attached stilbene chromophores at both ends have been investigated. As few as from two to four base bairs are needed to establish base-pair absorption and circular dichroism spectra similar to those of longer oligomers. The stilbene chromophores exhibit exciton-coupled circular dichroism, which can be observed even with 11 intervening base pairs, a distance of ca. 40 Å. The dependence of the sign and amplitude of these spectra reveals the ability of B-DNA to serve as a helical ruler.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja036449k