Mitotic and in situ end-labeling apoptotic indices as prognostic markers in malignant mesothelioma

The prognostic role of mitotic and apoptotic indices in 60 patients with malignant mesothelioma was examined on hematoxylin-eosin-stained sections. The findings were compared with apoptotic indices determined by in situ end labeling (ISEL) in 35 of the cases. There was a significant survival advanta...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2000-06, Vol.4 (3), p.143-148
Main Authors: Beer, Trevor W., Carr, Norman J., Whittaker, Mark A., Pullinger, Neil
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Apoptosis
Biopsy
Eosine Yellowish-(YS)
Female
Follow-Up Studies
Hematoxylin
Humans
In Situ Nick-End Labeling
Male
Mesothelioma - pathology
Middle Aged
Mitotic Index
Prognosis
Staining and Labeling
Survival Analysis
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Summary:The prognostic role of mitotic and apoptotic indices in 60 patients with malignant mesothelioma was examined on hematoxylin-eosin-stained sections. The findings were compared with apoptotic indices determined by in situ end labeling (ISEL) in 35 of the cases. There was a significant survival advantage associated with lower mitotic counts and a lower apoptotic index defined by ISEL ( P < .05). There was no association between the apoptotic index derived from the hematoxylin-eosinstained sections and prognosis (P = .90). However, there was a positive association between the apoptotic counts calculated from hematoxylin-eosin- and ISEL-stained sections ( P < .01). The mitotic count and ISEL apoptotic index are potentially useful markers of prognosis in malignant mesothelioma.
ISSN:1092-9134
1532-8198
DOI:10.1016/S1092-9134(00)90036-4