Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain

The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-h...

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Bibliographic Details
Published in:Indian journal of biochemistry & biophysics 2001-10, Vol.38 (5), p.327-330
Main Authors: Varghese, S, Shameena, B, Lakshmy, P S, Biju, M P, Easwar Shankar, P N, Paulose, C S, Oommen, O V
Format: Article
Language:English
Subjects:
Animals
Biogenic Monoamines - metabolism
Brain - drug effects
Brain - metabolism
Diet
Drug Combinations
Fatty Acids, Unsaturated - pharmacology
Hormones - metabolism
Male
Propylthiouracil - pharmacology
Rats
Rats, Wistar
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Summary:The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T3) (2.5 microg/100 g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine (NE) and epinephrine (EPI) contents were assayed in the hypothalamus and cerebral cortex regions. It was found that 6-PTU feeding resulted in decrease in dopamine, 5-HT, 5-HTP and 5-HIAA in both regions. In animals fed with PUFA followed by administration of T3, the DA level was found normal.
ISSN:0301-1208