The prevalence of anergy in Human Immunodeficiency Virus-infected adolescents and the association of delayed-type hypersensitivity with subject characteristics

Purpose: To examine the prevalence of anergy in HIV-infected adolescents and factors associated with its occurrence. Methods: Anergy was defined as less than 2mm induration to each of three intradermally applied antigens (Candida albicans, tetanus toxoid, and mumps) between 24 and 96 hours in a popu...

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Published in:Journal of adolescent health 2000-12, Vol.27 (6), p.384-390
Main Authors: Smith Rogers, Audrey, Ellenberg, Jonas H, Douglas, Steven D, Henry-Reid, Lisa, Peralta, Ligia, Wilson, Craig M
Format: Article
Language:English
Subjects:
Adolescent
Algorithms
Anergy
Biological and medical sciences
CD4-Positive T-Lymphocytes
Child
Clonal Anergy - immunology
Delayed-type hypersensitivity
Female
HIV infection
HIV Infections - epidemiology
HIV Infections - immunology
Human immunodeficiency virus
Human viral diseases
Humans
Hypersensitivity, Delayed - immunology
Infectious diseases
Logistic Models
Male
Medical sciences
Multivariate Analysis
Prevalence
Risk Factors
Skin Tests
United States - epidemiology
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral Load
Young people
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Summary:Purpose: To examine the prevalence of anergy in HIV-infected adolescents and factors associated with its occurrence. Methods: Anergy was defined as less than 2mm induration to each of three intradermally applied antigens (Candida albicans, tetanus toxoid, and mumps) between 24 and 96 hours in a population of HIV-infected adolescents aged 12–18 at entry in a national multicenter study of HIV disease progression. CD4 + T-cell counts and plasma HIV-1 RNA were measured in quality controlled laboratories. Factors associated with the probability of anergy were examined with contingency table comparisons, tree-structured classification, and logistic regression analyses. Results: Overall prevalence of anergy in this clinic-based population of 167 was 11% [7% in males and 12% in females ( p = 0.57)]. The sole significant predictor of anergy was decreased CD4 + T-cell count ( p = 0.005). Conclusion: The prevalence of anergy is low in this HIV-infected population compared to older infected cohorts. The occurrence of differential rates of anergy in particular age and sex groupings that may be related to intrinsic immunologic differences requires further study.
ISSN:1054-139X
1879-1972
DOI:10.1016/S1054-139X(00)00161-0