Genomic imprinting of a placental lactogen gene in Peromyscus

The mammalian genome contains over 30 genes whose expression is dependent upon their parent-of-origin. Of these imprinted genes the majority are involved in regulating the rate of fetal growth. In this report we show that in the deer mouse Peromyscusthe placental lactogen-1-variant ( pPl1-v) gene is...

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Bibliographic Details
Published in:Development genes and evolution 2001-12, Vol.211 (11), p.523-532
Main Authors: Vrana, P B, Matteson, P G, Schmidt, J V, Ingram, R S, Joyce, A, Prince, K L, Dewey, M J, Tilghman, S M
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Evolution, Molecular
Gene Expression
Genes
Genomic Imprinting
Genomics
Hybridization, Genetic - genetics
lactogen
Mice
Molecular Sequence Data
Multigene Family
Peromyscus
Phylogeny
Placenta - metabolism
Placental Lactogen - genetics
pPl1 gene
pPl1-v gene
Sequence Homology
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Summary:The mammalian genome contains over 30 genes whose expression is dependent upon their parent-of-origin. Of these imprinted genes the majority are involved in regulating the rate of fetal growth. In this report we show that in the deer mouse Peromyscusthe placental lactogen-1-variant ( pPl1-v) gene is paternally expressed throughout fetal development, whereas the linked and closely related pPl1gene is expressed in a biallelic manner. Neither the more distantly related pPl2Agene, nor the Mus Pl1gene displays any preferential expression of the paternal allele, suggesting that the acquisition of imprinting of pPl1-v is a relatively recent event in evolution. Although pPl1 expression is temporally mis-regulated in the dysplastic placentae of hybrids between two Peromyscus species, its over-expression cannot account for the aberrant phenotypes of these placentae. We argue that the species-specific imprinting of pPl1-v, encoding a growth factor that regulates nutrient transfer from mothers to their offspring, is consistent with the parent-offspring conflict model that has been proposed to explain the evolution of genomic imprinting.
ISSN:0949-944X
1432-041X
DOI:10.1007/s00427-001-0188-x