Proliferative activity, angiogenesis and nuclear morphometry in renal cell carcinoma

Background: Prognostic parameters other than tumor stage and grade are essential for renal cell carcinoma (RCC) patients. This study was undertaken to determine the usefulness of cellular proliferation, angiogenesis and nuclear morphometry in predicting the biological aggressiveness of RCC. Methods:...

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Bibliographic Details
Published in:International journal of urology 2001-12, Vol.8 (12), p.697-703
Main Authors: KIRKALI, ZIYA, YORUKOGLU, KUTSAL, OZKARA, ESRA, KAZIMOGLU, HATEM, MUNGAN, UGUR
Format: Article
Language:English
Subjects:
Adult
Aged
angiogenesis
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - therapy
Cell Nucleus - ultrastructure
Disease-Free Survival
Female
Humans
Immunohistochemistry
Ki-67
Ki-67 Antigen - analysis
kidney
Kidney Neoplasms - pathology
Kidney Neoplasms - therapy
Male
Middle Aged
morphometry
Multivariate Analysis
Neovascularization, Pathologic
renal cell carcinoma
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Summary:Background: Prognostic parameters other than tumor stage and grade are essential for renal cell carcinoma (RCC) patients. This study was undertaken to determine the usefulness of cellular proliferation, angiogenesis and nuclear morphometry in predicting the biological aggressiveness of RCC. Methods: Surgical specimens of 70 patients with RCC were investigated by conventional histology, Ki‐67 immunostaining and stereological assessment of angiogenesis and mean nuclear volume. Results: There was no difference in disease‐specific survival with respect to sex, age and histopathological type (except sarcomatoid and other types). The survival was significantly lower and the chance of metastases was higher in the group with higher proliferative activity (P = 0.007). There was no relation between angiogenesis, mean nuclear volume, stage and survival. There was a significant relation between both Fuhrman and WHO grades, tumor stage and survival. Histopathological type, grade, angiogenesis and mean nuclear volume failed to predict recurrences and/or metastases. In multivariate analysis, only TNM stage and proliferative activity were found to be independent prognostic factors. Conclusions: In addition to tumor grade and stage, proliferative activity of a given RCC may have the potential to identify patients with an impaired prognosis.
ISSN:0919-8172
1442-2042
DOI:10.1046/j.1442-2042.2001.00405.x