Sulfotransferases in glycosaminoglycan biosynthesis

Most of the sulfotransferases participating in glycosaminoglycan biosynthesis have now been identified. Their essential role in generating binding sites for proteins interacting with glycosaminoglycans is apparent. These interactions may influence important biological processes such as growth contro...

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Bibliographic Details
Published in:Current opinion in structural biology 2003-10, Vol.13 (5), p.605-611
Main Authors: Kusche-Gullberg, M, Kjellen, L
Format: Article
Language:English
Subjects:
Animals
Caenorhabditis elegans
Chondroitin Sulfates - biosynthesis
Chondroitin Sulfates - chemistry
Dermatan Sulfate - biosynthesis
Dermatan Sulfate - chemistry
Drosophila melanogaster
Glycosaminoglycans - biosynthesis
Glycosaminoglycans - chemistry
Heparitin Sulfate - biosynthesis
Heparitin Sulfate - chemistry
Humans
Keratan Sulfate - biosynthesis
Keratan Sulfate - chemistry
Mice
Multienzyme Complexes - chemistry
Multienzyme Complexes - metabolism
Sulfotransferases - chemistry
Sulfotransferases - metabolism
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Summary:Most of the sulfotransferases participating in glycosaminoglycan biosynthesis have now been identified. Their essential role in generating binding sites for proteins interacting with glycosaminoglycans is apparent. These interactions may influence important biological processes such as growth control, signal transduction, cell adhesion and lipid metabolism. Gene targeting in mice as well as studies in Drosophila melanogaster and Caenorhabditis elegans have shown that dysfunction or lack of glycosaminoglycan sulfotransferases may result in severely disturbed embryonic development.
ISSN:0959-440X
1879-033X
DOI:10.1016/j.sbi.2003.08.002