The XT-Tube Extractor:  A Hollow Fiber-Based Supported Liquid Membrane Extractor for Bioanalytical Sample Preparation

A new supported liquid membrane extractor for bioanalytical sample preparation is presented. The extractor consists of a polypropylene hollow fiber mounted inside a PTFE tube by means of a cross-connector and a tee-connector. All parts are commercially available, inexpensive, and easily assembled. A...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2003-07, Vol.75 (14), p.3506-3511
Main Authors: Jonsson, Ove B, Nordlöf, Ulrika, Nilsson, Ulrika L
Format: Article
Language:English
Subjects:
Analytical chemistry
Calibration
Chemistry
diphenyl phosphate ester
Exact sciences and technology
General, instrumentation
Humans
Indicators and Reagents
liquid membranes
Membranes, Artificial
organic solvents
polypropylene
Polytetrafluoroethylene
Reproducibility of Results
Spectrometric and optical methods
Spectrophotometry, Ultraviolet
Urine - chemistry
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Summary:A new supported liquid membrane extractor for bioanalytical sample preparation is presented. The extractor consists of a polypropylene hollow fiber mounted inside a PTFE tube by means of a cross-connector and a tee-connector. All parts are commercially available, inexpensive, and easily assembled. An organic solvent in the pores of the fiber forms a liquid membrane that separates the sample, which is pumped along the outside of the fiber, from the acceptor phase, which is pumped inside. The length of the hollow fiber may easily be varied to meet different demands on extractive surface and extract volumes. To test the system, the strongly acidic plasticizer/flame retardant metabolite diphenyl phosphate ester (DPhP), with a pK a value of 0.26, was extracted from urine. DPhP was protonated using 4 M hydrochloric acid and extracted into an acceptor phase at pH 9. Thirty extractions were made with the same liquid membrane without any decrease in extraction efficiency and with a relative standard deviation
ISSN:0003-2700
1520-6882
DOI:10.1021/ac034218q