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Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c- ski oncogene
We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c- ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced...
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Published in: | Cancer letters 2003-10, Vol.200 (2), p.153-160 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c-
ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced in the fast twitch muscles of c-
ski transgenic animals with respect to controls; in contrast, there are no detectable differences in the synthesis rates. The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways. |
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ISSN: | 0304-3835 1872-7980 |
DOI: | 10.1016/S0304-3835(03)00415-4 |