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Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c- ski oncogene

We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c- ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced...

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Bibliographic Details
Published in:Cancer letters 2003-10, Vol.200 (2), p.153-160
Main Authors: Costelli, Paola, Carbó, Neus, Busquets, Sı́lvia, López-Soriano, Francisco J, Baccino, Francesco M, Argilés, Josep M
Format: Article
Language:English
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Summary:We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c- ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced in the fast twitch muscles of c- ski transgenic animals with respect to controls; in contrast, there are no detectable differences in the synthesis rates. The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways.
ISSN:0304-3835
1872-7980
DOI:10.1016/S0304-3835(03)00415-4