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Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c- ski oncogene
We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c- ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced...
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| Published in: | Cancer letters 2003-10, Vol.200 (2), p.153-160 |
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| Main Authors: | , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c479t-2c440343adcad6a6ed69837134e00387e1a961e55313eabd57acf63d0d19a8c3 |
| container_end_page | 160 |
| container_issue | 2 |
| container_start_page | 153 |
| container_title | Cancer letters |
| container_volume | 200 |
| creator | Costelli, Paola Carbó, Neus Busquets, Sı́lvia López-Soriano, Francisco J Baccino, Francesco M Argilés, Josep M |
| description | We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c-
ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced in the fast twitch muscles of c-
ski transgenic animals with respect to controls; in contrast, there are no detectable differences in the synthesis rates. The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways. |
| doi_str_mv | 10.1016/S0304-3835(03)00415-4 |
| format | article |
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ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced in the fast twitch muscles of c-
ski transgenic animals with respect to controls; in contrast, there are no detectable differences in the synthesis rates. The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(03)00415-4</identifier><identifier>PMID: 14568169</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Body Weight ; c- ski ; c-ski gene ; Cancer ; Cloning ; DNA-Binding Proteins - genetics ; Embryos ; Gene expression ; Hypertrophy ; Laboratory animals ; Medical sciences ; Mice ; Mice, Transgenic ; Models, Biological ; Muscle Proteins - metabolism ; Muscle, Skeletal - pathology ; Muscular system ; Musculoskeletal system ; Organ Size ; Peptide Hydrolases ; Pharmacology. Drug treatments ; Protein turnover ; Proteins ; Proto-Oncogene Proteins - genetics ; Rodents ; Skeletal muscle hypertrophy ; Tumors ; Ubiquitin-dependent proteolytic pathway</subject><ispartof>Cancer letters, 2003-10, Vol.200 (2), p.153-160</ispartof><rights>2003 Elsevier Ireland Ltd</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Elsevier Limited Oct 28, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-2c440343adcad6a6ed69837134e00387e1a961e55313eabd57acf63d0d19a8c3</citedby><cites>FETCH-LOGICAL-c479t-2c440343adcad6a6ed69837134e00387e1a961e55313eabd57acf63d0d19a8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15217131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14568169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Costelli, Paola</creatorcontrib><creatorcontrib>Carbó, Neus</creatorcontrib><creatorcontrib>Busquets, Sı́lvia</creatorcontrib><creatorcontrib>López-Soriano, Francisco J</creatorcontrib><creatorcontrib>Baccino, Francesco M</creatorcontrib><creatorcontrib>Argilés, Josep M</creatorcontrib><title>Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c- ski oncogene</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c-
ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced in the fast twitch muscles of c-
ski transgenic animals with respect to controls; in contrast, there are no detectable differences in the synthesis rates. The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>c- ski</subject><subject>c-ski gene</subject><subject>Cancer</subject><subject>Cloning</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Embryos</subject><subject>Gene expression</subject><subject>Hypertrophy</subject><subject>Laboratory animals</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>Models, Biological</subject><subject>Muscle Proteins - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular system</subject><subject>Musculoskeletal system</subject><subject>Organ Size</subject><subject>Peptide Hydrolases</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein turnover</subject><subject>Proteins</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Rodents</subject><subject>Skeletal muscle hypertrophy</subject><subject>Tumors</subject><subject>Ubiquitin-dependent proteolytic pathway</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqFks1u1DAUhS0EotPCI4AsISpYBOz4J8mqQhV_UiUk6N5y7TszLkkcfJ1CHoj3xNMZqMSmKy_8neN7zzEhzzh7wxnXb78xwWQlWqFeMfGaMclVJR-QFW-bumq6lj0kq3_IETlGvGaMKdmox-SIS6VbrrsV-f0V_OzA0ynFDGGkHjbJeptDHGmyGZDa0dM-_qTwa0qAuLuI6z0f-yUHR3HBDANSnKcppkzxO_SQbU-HGV0PdLtMkHKK03ah5Ymc7IgbGItyCA5ovIH013zc0LwF6qpiEmgcXSwgPCGP1rZHeHo4T8jlh_eX55-qiy8fP5-_u6icbLpc1U5KJqSw3lmvrQavu1Y0XEhgTLQNcNtpDkoJLsBeedVYt9bCM8872zpxQk73tmW5HzNgNkNAB31vR4gzmobXnSwp3gvytlOy5ryAL_4Dr-OcxrKD4YopoVWtu0KpPeVSREywNlMKg02L4czs2ja3bZtdlYYJc9u2kUX3_OA-Xw3g71SHegvw8gBYdLZfl-BdwDtO1byksxvzbM9BCfcmQDLoAozlX4QELhsfwz2j_AG-qcpX</recordid><startdate>20031028</startdate><enddate>20031028</enddate><creator>Costelli, Paola</creator><creator>Carbó, Neus</creator><creator>Busquets, Sı́lvia</creator><creator>López-Soriano, Francisco J</creator><creator>Baccino, Francesco M</creator><creator>Argilés, Josep M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20031028</creationdate><title>Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c- ski oncogene</title><author>Costelli, Paola ; Carbó, Neus ; Busquets, Sı́lvia ; López-Soriano, Francisco J ; Baccino, Francesco M ; Argilés, Josep M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-2c440343adcad6a6ed69837134e00387e1a961e55313eabd57acf63d0d19a8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>c- ski</topic><topic>c-ski gene</topic><topic>Cancer</topic><topic>Cloning</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Embryos</topic><topic>Gene expression</topic><topic>Hypertrophy</topic><topic>Laboratory animals</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>Models, Biological</topic><topic>Muscle Proteins - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular system</topic><topic>Musculoskeletal system</topic><topic>Organ Size</topic><topic>Peptide Hydrolases</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein turnover</topic><topic>Proteins</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Rodents</topic><topic>Skeletal muscle hypertrophy</topic><topic>Tumors</topic><topic>Ubiquitin-dependent proteolytic pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Costelli, Paola</creatorcontrib><creatorcontrib>Carbó, Neus</creatorcontrib><creatorcontrib>Busquets, Sı́lvia</creatorcontrib><creatorcontrib>López-Soriano, Francisco J</creatorcontrib><creatorcontrib>Baccino, Francesco M</creatorcontrib><creatorcontrib>Argilés, Josep M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Costelli, Paola</au><au>Carbó, Neus</au><au>Busquets, Sı́lvia</au><au>López-Soriano, Francisco J</au><au>Baccino, Francesco M</au><au>Argilés, Josep M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c- ski oncogene</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2003-10-28</date><risdate>2003</risdate><volume>200</volume><issue>2</issue><spage>153</spage><epage>160</epage><pages>153-160</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>We have investigated the protein turnover modulations involved in the hypertrophic muscle phenotype of c-
ski overexpressing transgenic mice. In these animals, the body weight is increased and all the muscles examined show a definite hypertrophy. The protein degradation rate is significantly reduced in the fast twitch muscles of c-
ski transgenic animals with respect to controls; in contrast, there are no detectable differences in the synthesis rates. The down-regulation of protein breakdown is paralleled by decreased expression of genes belonging to the lysosomal as well as to the ATP-ubiquitin-dependent proteolytic pathways.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>14568169</pmid><doi>10.1016/S0304-3835(03)00415-4</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cancer letters, 2003-10, Vol.200 (2), p.153-160 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | Elsevier |
| subjects | Animals Antineoplastic agents Biological and medical sciences Body Weight c- ski c-ski gene Cancer Cloning DNA-Binding Proteins - genetics Embryos Gene expression Hypertrophy Laboratory animals Medical sciences Mice Mice, Transgenic Models, Biological Muscle Proteins - metabolism Muscle, Skeletal - pathology Muscular system Musculoskeletal system Organ Size Peptide Hydrolases Pharmacology. Drug treatments Protein turnover Proteins Proto-Oncogene Proteins - genetics Rodents Skeletal muscle hypertrophy Tumors Ubiquitin-dependent proteolytic pathway |
| title | Reduced protein degradation rates and low expression of proteolytic systems support skeletal muscle hypertrophy in transgenic mice overexpressing the c- ski oncogene |
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