Activation of the prefrontal cortex to trauma-related stimuli measured by near-infrared spectroscopy in posttraumatic stress disorder due to terrorism

To develop a noninvasive method for psychophysiological assessment of posttraumatic stress disorder (PTSD), 34 victims of the Tokyo Subway Sarin Attack in 1995 including 8 diagnosed as PTSD and 12 controls were examined by a multichannel near‐infrared spectroscopy (NIRS) system. Hemodynamic response...

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Bibliographic Details
Published in:Psychophysiology 2003-07, Vol.40 (4), p.492-500
Main Authors: Matsuo, Koji, Kato, Tadafumi, Taneichi, Kotaro, Matsumoto, Akio, Ohtani, Toshiyuki, Hamamoto, Taku, Yamasue, Hidenori, Sakano, Yuji, Sasaki, Tsukasa, Sadamatsu, Miyuki, Iwanami, Akira, Asukai, Nozomi, Kato, Nobumasa
Format: Article
Language:English
Subjects:
Adult
Female
Galvanic Skin Response
GSR
Heart Rate - physiology
Hemoglobin oxygenation
Hemoglobins - metabolism
Humans
Male
Middle Aged
Neuroimaging
Optical topography
Oxyhemoglobins - metabolism
Posttraumatic stress disorder
Prefrontal Cortex - pathology
Prefrontal Cortex - physiopathology
Skin conductance response
Spectroscopy, Near-Infrared
Stress Disorders, Post-Traumatic - pathology
Stress Disorders, Post-Traumatic - physiopathology
Terrorism - psychology
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Summary:To develop a noninvasive method for psychophysiological assessment of posttraumatic stress disorder (PTSD), 34 victims of the Tokyo Subway Sarin Attack in 1995 including 8 diagnosed as PTSD and 12 controls were examined by a multichannel near‐infrared spectroscopy (NIRS) system. Hemodynamic response in the prefrontal cortex was monitored during the presentation of trauma‐related and control stimuli by video images. Skin conductance response (SCR) was also examined. Oxygenated hemoglobin significantly increased during the trauma‐related image in the victims with or without PTSD. Deoxygenated hemoglobin significantly decreased only in victims with PTSD. No significant alteration was found in controls. Significantly enhanced SCR was also observed in the victims with PTSD during trauma‐related stimuli. The findings suggest that measurement of cerebral hemodynamic response by NIRS is useful for psychophysiological assessment of PTSD.
ISSN:0048-5772
1469-8986
DOI:10.1111/1469-8986.00051