Role of Gastrointestinal Hormones in the Proliferation of Normal and Neoplastic Tissues

Gastrointestinal (GI) hormones are chemical messengers that regulate the physiological functions of the intestine and pancreas, including secretion, motility, absorption, and digestion. In addition to these well-defined physiological effects, GI hormones can stimulate proliferation of the nonneoplas...

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Bibliographic Details
Published in:Endocrine reviews 2003-10, Vol.24 (5), p.571-599
Main Authors: Thomas, Robert P, Hellmich, Mark R, Townsend, Courtney M, Evers, B. Mark
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Division
Cholecystokinin
Fundamental and applied biological sciences. Psychology
Gastrin
Gastrin-releasing peptide
Gastrointestinal Diseases - therapy
Gastrointestinal Hormones - analysis
Gastrointestinal Hormones - physiology
Gastrointestinal Neoplasms - pathology
Gastrointestinal Neoplasms - therapy
Glucagon
Glucagon-like peptide 2
Hormones
Humans
Intestine
Neurotensin
Pancreas
Pancreatic cancer
Peptides
Physiological effects
Physiology
Prostate cancer
Receptors
Receptors, Gastrointestinal Hormone
Signal Transduction
Somatostatin
Vertebrates: endocrinology
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Summary:Gastrointestinal (GI) hormones are chemical messengers that regulate the physiological functions of the intestine and pancreas, including secretion, motility, absorption, and digestion. In addition to these well-defined physiological effects, GI hormones can stimulate proliferation of the nonneoplastic intestinal mucosa and pancreas. Furthermore, in an analogous fashion to breast and prostate cancer, certain GI cancers possess receptors for GI hormones; growth can be altered by administration of these hormones or by blocking their respective receptors. The GI hormones that affect proliferation, either stimulatory or inhibitory, include gastrin, cholecystokinin, gastrin-releasing peptide, neurotensin, peptide YY, glucagon-like peptide-2, and somatostatin. The effects of these peptides on normal and neoplastic GI tissues will be described. Also, future perspectives and potential therapeutic implications will be discussed.
ISSN:0163-769X
1945-7189
DOI:10.1210/er.2002-0028