The Double Life of Ribosomal Proteins

Many integral proteins of the ribosome also carry out extra-ribosomal functions as independent polypeptides, raising questions as to their evolutionary derivation. In this issue of Cell, Mazumder et al. report a surprising new twist in the dual life of these molecules: as part of a cellular response...

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Bibliographic Details
Published in:Cell 2003-10, Vol.115 (2), p.130-132
Main Author: Zimmermann, Robert A
Format: Article
Language:English
Subjects:
Cells, Cultured
Interferon-gamma - pharmacology
Monocytes - drug effects
Protein Binding
Protein Biosynthesis
Ribosomal Proteins - metabolism
Ribosomes - metabolism
RNA, Messenger - genetics
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Summary:Many integral proteins of the ribosome also carry out extra-ribosomal functions as independent polypeptides, raising questions as to their evolutionary derivation. In this issue of Cell, Mazumder et al. report a surprising new twist in the dual life of these molecules: as part of a cellular response to interferon, a large-subunit protein dramatically exits the ribosome to bind and inhibit the translation of a specific mRNA.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(03)00804-3