Hsp27: Novel Regulator of Intracellular Redox State

Small stress proteins are molecular chaperones that modulate the ability of cells to respond to several types of injuries. In this regard, a protection generated by the expression of mammalian small stress proteins against the cell death induced by oxidative stress has been described. This review su...

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Bibliographic Details
Published in:IUBMB life 2001-12, Vol.52 (6), p.303-307
Main Author: Arrigo, André‐Patrick
Format: Article
Language:English
Subjects:
Animals
Cell Death
Chaperonins - metabolism
Heat-Shock Proteins
HSP27 Heat-Shock Proteins
Humans
Models, Biological
Neoplasm Proteins - chemistry
Neoplasm Proteins - metabolism
Oxidation-Reduction
Oxidative Stress
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Summary:Small stress proteins are molecular chaperones that modulate the ability of cells to respond to several types of injuries. In this regard, a protection generated by the expression of mammalian small stress proteins against the cell death induced by oxidative stress has been described. This review summarizes the current knowledge of the protective mechanism generated by the expression of the major mammalian small stress protein Hsp27 in cells exposed to oxidative stress. A possible role of this chaperon protein in the presentation of oxidized proteins to the proteasome degradation machinery is proposed.
ISSN:1521-6543
1521-6551
DOI:10.1080/152165401317291156