Mechanisms of Pathogenicity of Influenza A (H5N1) Viruses in Mice

Avian-like H5N1 influenza viruses isolated from humans in 1997 were shown to have two distinct pathogenic phenotypes in BALB/c mice, after intranasal inoculation and without prior adaptation to this host. To further understand the mechanisms of H5N1 pathogenicity, we investigated the consequences of...

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Bibliographic Details
Published in:Avian diseases 2003-01, Vol.47 (s3), p.1131-1134
Main Authors: Bright, R. A, Cho, D. S, Rowe, T, Katz, J. M
Format: Article
Language:English
Subjects:
Animals
avian influenza
Blood
Brain - virology
Female
H5N1
H5N1 subtype influenza A virus
Humans
Influenza A virus
Influenza A Virus, H5N1 Subtype - classification
Influenza A Virus, H5N1 Subtype - isolation & purification
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza, Human - physiopathology
Inoculation
Lung - virology
Lungs
Lymphocyte depletion
Lymphocytes
Mice
Mice, Inbred BALB C
Orthomyxoviridae
Orthomyxoviridae Infections - physiopathology
Orthomyxoviridae Infections - transmission
Orthomyxoviridae Infections - virology
orthomyxovirus
pathogenesis
Poster Presentations
Virus Replication
Viruses
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Summary:Avian-like H5N1 influenza viruses isolated from humans in 1997 were shown to have two distinct pathogenic phenotypes in BALB/c mice, after intranasal inoculation and without prior adaptation to this host. To further understand the mechanisms of H5N1 pathogenicity, we investigated the consequences of the route of viral inoculation on morbidity and mortality, viral replication in pulmonary and systemic organs, and lymphocyte depletion. This study demonstrates the importance of extrapulmonary spread and replication, particularly in the brain, for the lethality of H5N1 viruses.
ISSN:0005-2086
1938-4351
DOI:10.1637/0005-2086-47.s3.1131