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Mechanisms of Pathogenicity of Influenza A (H5N1) Viruses in Mice

Avian-like H5N1 influenza viruses isolated from humans in 1997 were shown to have two distinct pathogenic phenotypes in BALB/c mice, after intranasal inoculation and without prior adaptation to this host. To further understand the mechanisms of H5N1 pathogenicity, we investigated the consequences of...

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Published in:	Avian diseases 2003-01, Vol.47 (s3), p.1131-1134
Main Authors:	Bright, R. A, Cho, D. S, Rowe, T, Katz, J. M
Format:	Article
Language:	English
Subjects:	Animals avian influenza Blood Brain - virology Female H5N1 H5N1 subtype influenza A virus Humans Influenza A virus Influenza A Virus, H5N1 Subtype - classification Influenza A Virus, H5N1 Subtype - isolation & purification Influenza A Virus, H5N1 Subtype - pathogenicity Influenza, Human - physiopathology Inoculation Lung - virology Lungs Lymphocyte depletion Lymphocytes Mice Mice, Inbred BALB C Orthomyxoviridae Orthomyxoviridae Infections - physiopathology Orthomyxoviridae Infections - transmission Orthomyxoviridae Infections - virology orthomyxovirus pathogenesis Poster Presentations Virus Replication Viruses
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description	Avian-like H5N1 influenza viruses isolated from humans in 1997 were shown to have two distinct pathogenic phenotypes in BALB/c mice, after intranasal inoculation and without prior adaptation to this host. To further understand the mechanisms of H5N1 pathogenicity, we investigated the consequences of the route of viral inoculation on morbidity and mortality, viral replication in pulmonary and systemic organs, and lymphocyte depletion. This study demonstrates the importance of extrapulmonary spread and replication, particularly in the brain, for the lethality of H5N1 viruses.
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subjects	Animals avian influenza Blood Brain - virology Female H5N1 H5N1 subtype influenza A virus Humans Influenza A virus Influenza A Virus, H5N1 Subtype - classification Influenza A Virus, H5N1 Subtype - isolation & purification Influenza A Virus, H5N1 Subtype - pathogenicity Influenza, Human - physiopathology Inoculation Lung - virology Lungs Lymphocyte depletion Lymphocytes Mice Mice, Inbred BALB C Orthomyxoviridae Orthomyxoviridae Infections - physiopathology Orthomyxoviridae Infections - transmission Orthomyxoviridae Infections - virology orthomyxovirus pathogenesis Poster Presentations Virus Replication Viruses
title	Mechanisms of Pathogenicity of Influenza A (H5N1) Viruses in Mice
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