Automated multiple-layer spotting for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of synthetic polymers utilizing ink-jet printing technology

Recently, a new multiple‐layer matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS) sample spotting technique for poly(ethylene glycol), offering improved analysis possibilities, was described. In this contribution the application of ink‐jet printing to automate...

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Bibliographic Details
Published in:Rapid communications in mass spectrometry 2003-01, Vol.17 (20), p.2349-2353
Main Authors: Meier, Michael A. R., de Gans, Berend-Jan, van den Berg, Antje M. J., Schubert, Ulrich S.
Format: Article
Language:English
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Summary:Recently, a new multiple‐layer matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOFMS) sample spotting technique for poly(ethylene glycol), offering improved analysis possibilities, was described. In this contribution the application of ink‐jet printing to automated, multiple‐layer MALDI‐TOFMS sample preparation of synthetic polymers is presented, allowing accurate deposition of matrix, additive and analyte solutions. The new sample preparation technique was evaluated for poly(ethylene glycol) as well as poly(methyl methacrylate) standards, and optimized settings for both synthetic polymers have been obtained. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.1195